Assessment of myocardial injuries in ischemic and non-ischemic cardiomyopathies using magnetic resonance T1-rho mapping.

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Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_AB6666BEAEFC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Assessment of myocardial injuries in ischemic and non-ischemic cardiomyopathies using magnetic resonance T1-rho mapping.
Journal
European heart journal. Cardiovascular Imaging
Author(s)
Bustin A., Pineau X., Sridi S., van Heeswijk R.B., Jaïs P., Stuber M., Cochet H.
ISSN
2047-2412 (Electronic)
ISSN-L
2047-2404
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
To identify clinical correlates of myocardial T1ρ and to examine how myocardial T1ρ values change under various clinical scenarios.
A total of 66 patients (26% female, median age 57 years [Q1-Q3, 44-65 years]) with known structural heart disease and 44 controls (50% female, median age 47 years [28-57 years]) underwent cardiac magnetic resonance imaging at 1.5-T, including T1ρ mapping, T2 mapping, native T1 mapping, late gadolinium enhancement, and ECV imaging.In controls, T1ρ positively related with T2 (P=0.038) and increased from basal to apical levels (P<0.001). As compared to controls and remote myocardium, T1ρ significantly increased in all patients' sub-groups and all types of myocardial injuries: acute and chronic injuries, focal and diffuse tissue abnormalities, as well as ischemic and non-ischemic aetiologies (P<0.05). T1ρ was independently associated with T2 in patients with acute injuries (P=0.004) and with native T1 and ECV in patients with chronic injuries (P<0.05). Myocardial T1ρ mapping demonstrated good intra- and interobserver reproducibility (ICC=0.86 and 0.83, respectively).
Myocardial T1ρ mapping appears to be reproducible and equally sensitive to acute and chronic myocardial injuries, whether of ischemic or non-ischemic origins. It may thus be a contrast-agent-free biomarker for gaining new and quantitative insight into myocardial structural disorders. These findings highlight the need for further studies through prospective and randomized trials.
Keywords
T1-rho, cardiomyopathy, cardiovascular magnetic resonance, myocardial scar
Pubmed
Open Access
Yes
Create date
23/11/2023 14:14
Last modification date
13/12/2023 7:22
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