Fetal programming and epigenetic mechanisms in arterial hypertension.

Details

Serval ID
serval:BIB_AB430A951C69
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Fetal programming and epigenetic mechanisms in arterial hypertension.
Journal
Current Opinion In Cardiology
Author(s)
Scherrer U., Rimoldi S.F., Sartori C., Messerli F.H., Rexhaj E.
ISSN
1531-7080 (Electronic)
ISSN-L
0268-4705
Publication state
Published
Issued date
07/2015
Peer-reviewed
Oui
Volume
30
Number
4
Pages
393-397
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
PURPOSE OF REVIEW: To provide an overview of available evidence of the potential role of epigenetics in the pathogenesis of hypertension and vascular dysfunction.
RECENT FINDINGS: Arterial hypertension is a highly heritable condition. Surprisingly, however, genetic variants only explain a tiny fraction of the phenotypic variation and the term 'missing heritability' has been coined to describe this phenomenon. Recent evidence suggests that phenotypic alteration that is unrelated to changes in DNA sequence (thereby escaping detection by classic genetic methodology) offers a potential explanation. Here, we present some basic information on epigenetics and review recent work consistent with the hypothesis of epigenetically induced arterial hypertension.
SUMMARY: New technologies that enable the rigorous assessment of epigenetic changes and their phenotypic consequences may provide the basis for explaining the missing heritability of arterial hypertension and offer new possibilities for treatment and/or prevention.
Keywords
Epigenesis, Genetic, Female, Fetal Development, Gene-Environment Interaction, Genetic Predisposition to Disease, Genetic Variation, Humans, Hypertension/genetics, Pregnancy
Pubmed
Web of science
Create date
29/07/2015 13:38
Last modification date
20/08/2019 15:15
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