Venous thromboembolism characteristics, treatment and outcomes in young adults: findings from the Registro Informatizado de Enfermedad TromboEmbólica registry.
Details
Serval ID
serval:BIB_AB41E6C5F859
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Venous thromboembolism characteristics, treatment and outcomes in young adults: findings from the Registro Informatizado de Enfermedad TromboEmbólica registry.
Journal
Journal of thrombosis and haemostasis
Working group(s)
RIETE Investigators
Contributor(s)
Monreal M., Prandoni P., Brenner B., Farge-Bancel D., Barba R., Di Micco P., Bertoletti L., Schellong S., Tzoran I., Reis A., Bosevski M., Bounameaux H., Malý R., Verhamme P., Caprini J.A., Bui H.M., Adarraga M.D., Alberich-Conesa A., Alonso-Carrillo J., Amado C., Amorós S., Arcelus J.I., Ballaz A., Barba R., Barbagelata C., Barrón M., Barrón-Andrés B., Blanco-Molina A., Botella E., Casado I., Chasco L., Cerdà P., Criado J., Del Toro J., De Juana-Izquierdo C., Demelo-Rodríguez P., Díaz-Brasero A.M., Díaz-Pedroche M.C., Díaz-Peromingo J.A., Dubois-Silva A., Escribano J.C., Espósito F., Falgá C., Fernández-Capitán C., Fernández-Jiménez B., Fernández-Muixi J., Fernández-Reyes J.L., Fidalgo M.A., Font C., Francisco I., Galeano-Valle F., García M.A., García de Herreros M., García-Bragado F., García-Ortega A., Gavín-Sebastián O., Gil-Díaz A., Gómez-Cuervo C., Gómez-Mosquera A.M., González-Martínez J., González-Moreno M., Grau E., Guirado L., Gutiérrez J., Hernández-Blasco L., Jaras M.J., Jiménez D., Jou I., Joya M.D., Lacruz B., Lainez-Justo S., Lalueza A., Latorre A., Lecumberri R., Lobo J.L., López-De la Fuente M., López-Jiménez L., López-Miguel P., López-Núñez J.J., López-Ruiz A., López-Sáez J.B., Lorenzo A., Lumbierres M., Madridano O., Maestre A., Marcos M., Martín-Martos F., Mellado M., Mena E., Mercado M.I., Moisés J., Monreal M., Muñoz-Blanco A., Muñoz-Gamito G., Morales M.V., Nieto J.A., Noguera-Gras E., Núñez-Fernández M.J., Osorio J., Otalora S., Pacheco-Gómez N., Paredes-Ruiz D., Parra P., Pedrajas J.M., Pérez-Ductor C., Pérez-Jacoiste M.A., Pérez-Pérez J.L., Peris M.L., Porras J.A., Poyo-Molina J., Puchades R., Riera-Mestre A., Rivera-Civico F., Rivera-Gallego A., Roca M., Rosa V., Rodríguez-Cobo A., Ruiz-Giménez N., Salgueiro G., Sancho T., Sendín V., Sigüenza P., Soler S., Suriñach J.M., Tiberio G., Torres M.I., Trujillo-Santos J., Uresandi F., Usandizaga E., Valle R., Varona J.F., Vela L., Vela J.R., Villalobos A., Villares P., Ay C., Nopp S., Pabinger I., Engelen M.M., Martens C., Verhamme P., Yoo HHB, Arguello J.D., Montenegro A.C., Roa J., Hirmerova J., Malý R., Accassat S., Bertoletti L., Bura-Riviere A., Catella J., Chopard R., Couturaud F., Espitia O., Leclercq B., Le Mao R., Mahé I., Moustafa F., Plaisance L., Poenou G., Sarlon-Bartoli G., Suchon P., Versini E., Schellong S., Braester A., Brenner B., Kenet G., Tzoran I., Sadeghipour P., Basaglia M., Bilora F., Bortoluzzi C., Brandolin B., Ciammaichella M., Colaizzo D., De Angelis A., Dentali F., Di Micco P., Grandone E., Imbalzano E., Merla S., Pesavento R., Prandoni P., Scarinzi P., Siniscalchi C., Tufano A., Visonà A., Vo Hong N., Zalunardo B., Gibietis V., Kigitovica D., Skride A., Fonseca S., Manuel M., Meireles J., Bosevski M., Bounameaux H., Mazzolai L., Aujayeb A., Caprini J.A., Weinberg I., Bui H.M.
ISSN
1538-7836 (Electronic)
ISSN-L
1538-7836
Publication state
Published
Issued date
10/2023
Peer-reviewed
Oui
Volume
21
Number
10
Pages
2811-2823
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Venous thromboembolism (VTE) is rare in patients aged <21 years. Young adults aged 18 to 21 years are frequently included in adult VTE studies, whereas pediatric VTE studies include patients aged up to either 18 or 21 years. The clinical characteristics of young adult patients with VTE have not been well defined.
We aimed to highlight any unique characteristics or treatment considerations that may apply to young adult patients with VTE.
Data from the prospective, international Registro Informatizado de Enfermedad TromboEmbólica registry were used. Patients were stratified into subcohorts according to age. The clinical characteristics, risk factors, management, and outcomes of young adult patients with VTE were compared with those of adolescents aged 12 to 18 years and adults aged >21 years.
Of 104 253 Registro Informatizado de Enfermedad TromboEmbólica patients enrolled until August 2022, 234 were adolescents and 884 were young adults. Less cases of pulmonary embolism were reported in adolescents (P < .001). Estrogen use was a common risk factor, more prevalent in adolescents and young adults (P < .001), whereas active cancer and immobilization were uncommon in both. Most patients were initially treated with low-molecular-weight heparin. VTE recurrence, major bleeding, and all-cause mortality rates were comparably low among adolescents and young adults. None of the patients aged <21 years died from VTE recurrence.
Young adults have some distinctive VTE risk factors. While VTE presentation may be similar among young adults and older patients, the outcomes of patients aged <21 years are more favorable.
We aimed to highlight any unique characteristics or treatment considerations that may apply to young adult patients with VTE.
Data from the prospective, international Registro Informatizado de Enfermedad TromboEmbólica registry were used. Patients were stratified into subcohorts according to age. The clinical characteristics, risk factors, management, and outcomes of young adult patients with VTE were compared with those of adolescents aged 12 to 18 years and adults aged >21 years.
Of 104 253 Registro Informatizado de Enfermedad TromboEmbólica patients enrolled until August 2022, 234 were adolescents and 884 were young adults. Less cases of pulmonary embolism were reported in adolescents (P < .001). Estrogen use was a common risk factor, more prevalent in adolescents and young adults (P < .001), whereas active cancer and immobilization were uncommon in both. Most patients were initially treated with low-molecular-weight heparin. VTE recurrence, major bleeding, and all-cause mortality rates were comparably low among adolescents and young adults. None of the patients aged <21 years died from VTE recurrence.
Young adults have some distinctive VTE risk factors. While VTE presentation may be similar among young adults and older patients, the outcomes of patients aged <21 years are more favorable.
Keywords
Adolescent, Humans, Young Adult, Child, Venous Thromboembolism/diagnosis, Venous Thromboembolism/drug therapy, Venous Thromboembolism/epidemiology, Prospective Studies, Pulmonary Embolism/diagnosis, Pulmonary Embolism/epidemiology, Pulmonary Embolism/therapy, Registries, Recurrence, Treatment Outcome, Anticoagulants/therapeutic use, adolescents, anticoagulants, venous thromboembolism, young adults
Pubmed
Web of science
Create date
07/07/2023 8:59
Last modification date
20/12/2023 7:16
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