Immunohistochemical Biomarkers of Gastrointestinal, Pancreatic, Pulmonary, and Thymic Neuroendocrine Neoplasms.

Details

Serval ID
serval:BIB_AB309A2F401C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Immunohistochemical Biomarkers of Gastrointestinal, Pancreatic, Pulmonary, and Thymic Neuroendocrine Neoplasms.
Journal
Endocrine pathology
Author(s)
Uccella S., La Rosa S., Volante M., Papotti M.
ISSN
1559-0097 (Electronic)
ISSN-L
1046-3976
Publication state
Published
Issued date
06/2018
Peer-reviewed
Oui
Volume
29
Number
2
Pages
150-168
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Neuroendocrine neoplasms (NENs) are a heterogeneous group of epithelial neoplastic proliferations that irrespective of their primary site share features of neural and endocrine differentiation including the presence of secretory granules, synaptic-like vesicles, and the ability to produce amine and/or peptide hormones. NENs encompass a wide spectrum of neoplasms ranging from well-differentiated indolent tumors to highly aggressive poorly differentiated neuroendocrine carcinomas. Most cases arise in the digestive system and in thoracic organs, i.e., the lung and thymus. A correct diagnostic approach is crucial for the management of patients with both digestive and thoracic NENs, because their high clinical and biological heterogeneity is related to their prognosis and response to therapy. In this context, immunohistochemistry represents an indispensable diagnostic tool that pathologists need to use for the correct diagnosis and classification of such neoplasms. In addition, immunohistochemistry is also useful in identifying prognostic and theranostic markers. In the present article, the authors will review the role of immunohistochemistry in the routine workup of digestive and thoracic NENs.
Keywords
Biomarkers, Tumor/analysis, Gastrointestinal Neoplasms/diagnosis, Humans, Immunohistochemistry/methods, Lung Neoplasms/diagnosis, Neuroendocrine Tumors/diagnosis, Pancreatic Neoplasms/diagnosis, Pathology, Clinical/methods, Thymus Neoplasms/diagnosis, Diagnosis, prognosis, Immunohistochemistry, Neuroendocrine carcinoma, Neuroendocrine tumor
Pubmed
Web of science
Open Access
Yes
Create date
13/03/2018 9:37
Last modification date
20/08/2019 15:15
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