Higher differentiation among subspecies of the house mouse (Mus musculus) in genomic regions with low recombination.

Details

Ressource 1Request a copy Sous embargo indéterminé.
State: Public
Version: author
Serval ID
serval:BIB_AB2CFFE0E8D3
Type
Article: article from journal or magazin.
Collection
Publications
Title
Higher differentiation among subspecies of the house mouse (Mus musculus) in genomic regions with low recombination.
Journal
Molecular Ecology
Author(s)
Geraldes A., Basset P., Smith K.L., Nachman M.W.
ISSN
1365-294X (Electronic)
ISSN-L
0962-1083
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
20
Number
22
Pages
4722-4736
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
In the early stages of reproductive isolation, genomic regions of reduced recombination are expected to show greater levels of differentiation, either because gene flow between species is reduced in these regions or because the effects of selection at linked sites within species are enhanced in these regions. Here, we study the patterns of DNA sequence variation at 27 autosomal loci among populations of Mus musculus musculus, M. m. domesticus, and M. m. castaneus, three subspecies of house mice with collinear genomes. We found that some loci exhibit considerable shared variation among subspecies, while others exhibit fixed differences. We used an isolation-with-gene-flow model to estimate divergence times and effective population sizes (N(e) ) and to disentangle ancestral variation from gene flow. Estimates of divergence time indicate that all three subspecies diverged from one another within a very short period of time approximately 350,000 years ago. Overall, N(e) for each subspecies was associated with the degree of genetic differentiation: M. m. musculus had the smallest N(e) and the greatest proportion of monophyletic gene genealogies, while M. m. castaneus had the largest N(e) and the smallest proportion of monophyletic gene genealogies. M. m. domesticus and M. m. musculus were more differentiated from each other than either were from M. m. castaneus, consistent with greater reproductive isolation between M. m. domesticus and M. m. musculus. F(ST) was significantly greater at loci experiencing low recombination rates compared to loci experiencing high recombination rates in comparisons between M. m. castaneus and M. m. musculus or M. m. domesticus. These results provide evidence that genomic regions with less recombination show greater differentiation, even in the absence of chromosomal rearrangements.
Keywords
Animals, Europe, Gene Flow, Genetic Loci, Genetic Variation, Genetics, Population, India, Likelihood Functions, Mice/classification, Mice/genetics, Models, Genetic, Recombination, Genetic, Sequence Analysis, DNA, Species Specificity
Pubmed
Web of science
Create date
04/03/2015 8:19
Last modification date
20/08/2019 15:15
Usage data