Impact of Delaying Antiretroviral Treatment during Primary HIV Infection on Telomere Length.

Details

Serval ID
serval:BIB_AB2761A109CD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Impact of Delaying Antiretroviral Treatment during Primary HIV Infection on Telomere Length.
Journal
The Journal of infectious diseases
Author(s)
Raffenberg M., Engel T., Schoepf I.C., Kootstra N.A., Reiss P., Braun D.L., Thorball C.W., Fellay J., Kouyos R.D., Ledergerber B., Günthard H.F., Tarr P.E.
Working group(s)
Zurich Primary HIV Infection Study and the Swiss HIV Cohort Study
ISSN
1537-6613 (Electronic)
ISSN-L
0022-1899
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Telomere length (TL) shortens during aging, HIV-seroconversion and untreated chronic HIV infection. It is unknown whether early antiretroviral therapy (ART) start is associated with less TL shortening during primary HIV infection (PHI).
We measured TL in peripheral blood mononuclear cells by quantitative PCR in participants of the Zurich PHI Study with samples available for >6 years. We obtained uni-/multivariable estimates from mixed-effects models and evaluated the association of delaying ART start or interrupting ART with baseline and longitudinal TL.
In 105 participants with PHI (median age 36 years, 9% women), median ART delay was 25, 42, and 60 days, respectively, in the 1 st (shortest), 2 nd, and 3 rd (longest) ART delay tertile. First ART delay tertile was associated with longer baseline TL (p for trend=0.034), and longer TL over 6 years, but only with continuous ART (p<0.001), not if ART was interrupted >12 months (p=0.408). In multivariable analysis, participants in the 2 nd and 3 rd ART delay tertile had 17.6% (5.4-29.7%; p=0.004) and 21.5% (9.4-33.5%; p<0.001) shorter TL, after adjustment for age, with limited effect modification by clinical variables.
In PHI, delaying ART start for even a matter of weeks was associated with significant and sustained TL shortening.
Keywords
HIV infection, antiretroviral therapy, multivariable analysis, primary HIV infection, telomere length
Pubmed
Create date
12/04/2021 12:16
Last modification date
30/04/2021 6:38
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