Clinical spectrum of COVID-19 complications in young adults: combined analysis of the American Heart Association COVID-19 Cardiovascular Disease Registry and the Outcomes Registry for Cardiac Conditions in Athletes.

Details

Serval ID
serval:BIB_AB225C02FF99
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Clinical spectrum of COVID-19 complications in young adults: combined analysis of the American Heart Association COVID-19 Cardiovascular Disease Registry and the Outcomes Registry for Cardiac Conditions in Athletes.
Journal
BMJ open
Author(s)
Bavishi A., Kliethermes S.A., Petek B., Moulson N., Mellacheruvu P., Churchill T.W., Harmon K., Patel M.R., Baggish A.L., Drezner J.A., Mutharasan R.K.
ISSN
2044-6055 (Electronic)
ISSN-L
2044-6055
Publication state
Published
Issued date
12/04/2023
Peer-reviewed
Oui
Volume
13
Number
4
Pages
e069943
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
While young adults 18-24 years old bear a significant proportion of COVID-19 diagnoses, the risk factors for hospitalisation and severe COVID-19 complications in this population are poorly understood.
The objective of this study was to identify risk factors for hospitalisation and other COVID-19 complications across the health spectrum of young adults diagnosed with COVID-19 infection.
Retrospective cohort study.
Young adults (aged 18-24) with confirmed COVID-19 infection from the American Heart Association (AHA) COVID-19 Cardiovascular Disease Registry of hospitalised patients and the Outcomes Registry for Cardiac Conditions in Athletes (ORCCA) study of collegiate athletes. The AHA registry included 636 young adults from 152 hospitals. The ORCCA registry consisted of 3653 competitive college athletes from 42 colleges and universities.
None (exposure to COVID-19).
Main outcomes included hospitalisation, death, major adverse cardiovascular events (MACE) and other severe clinical events.
In comparison to the ORCCA registry, patients in the AHA registry were more likely to be female (59% vs 33%); had higher average body mass index (BMI) (32.4 vs 25.6); and had increased prevalence of diabetes (10% vs 0.4%), hypertension (7% vs 0.6%), chronic kidney disease (2% vs 0%) and asthma (14% vs 8%), all with p<0.01. There were eight (2%) deaths in the AHA hospitalised registry compared with zero in the ORCCA cohort. BMI was a statistically significant predictor of death in the hospitalised cohort (OR 1.05, 95% CI 1.00, 1.10). No significant predictors of MACE or other severe clinical events were identified.
The risk of cardiac events in young adults aged 18-24 diagnosed with COVID-19 infection is low. Patients who were hospitalised (AHA registry) were more likely to have pre-existing medical comorbidities and higher BMI than healthy collegiate athletes (ORCCA registry). Once hospitalised, elevated BMI is associated with increased mortality although other drivers of MACE and other severe clinical events remain unclear.
Keywords
United States/epidemiology, Humans, Female, Young Adult, Adolescent, Adult, Male, Cardiovascular Diseases, COVID-19/complications, COVID-19/epidemiology, Retrospective Studies, American Heart Association, Heart Diseases/complications, Athletes, Registries, Adult cardiology, COVID-19, PUBLIC HEALTH
Pubmed
Web of science
Open Access
Yes
Create date
17/04/2023 12:10
Last modification date
18/11/2023 7:08
Usage data