Simvastatin lowers reactive oxygen species level by Nrf2 activation via PI3K/Akt pathway.
Details
Serval ID
serval:BIB_AB1C99FFA90F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Simvastatin lowers reactive oxygen species level by Nrf2 activation via PI3K/Akt pathway.
Journal
Biochemical and biophysical research communications
ISSN
1090-2104 (Electronic)
ISSN-L
0006-291X
Publication state
Published
Issued date
28/05/2010
Peer-reviewed
Oui
Volume
396
Number
2
Pages
463-466
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
The beneficial effects of HMG-CoA (3-hydroxy-3-methyl-glutaryl-CoA) reductase inhibitors (statins) have been attributed not only to their cholesterol lowering effect but also to their pleiotropic actions and especially to their anti-oxidant activity. Nrf2 (NF-E2-related factor 2) is a transcription factor that orchestrates the transcriptional response of cells to oxidative stressors and electrophilic xenobiotics. In this study, primary mouse embryonic fibroblasts from wild type or Nrf2 knock out C57BL6J mice and ST-2 cells were used to investigate the implication of Nrf2 in the mediation of the anti-oxidant effects of statins and the possible involvement of PI3K/Akt pathway in this process. We show for the first time that simvastatin lowers reactive oxygen species (ROS) by activating Nrf2 through the PI3K/Akt pathway.
Keywords
Animals, Cell Line, Glucose Oxidase/metabolism, Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology, Mice, Mice, Knockout, NF-E2-Related Factor 2/biosynthesis, NF-E2-Related Factor 2/genetics, Oxidative Stress/drug effects, Phosphatidylinositol 3-Kinases/metabolism, Proto-Oncogene Proteins c-akt/metabolism, Reactive Oxygen Species/antagonists & inhibitors, Simvastatin/pharmacology
Pubmed
Web of science
Create date
03/09/2023 20:25
Last modification date
23/09/2023 6:55
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