Chronic hepatitis C infection in a patient with bone marrow hypoplasia.

Details

Serval ID
serval:BIB_AB039EEEDE46
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Chronic hepatitis C infection in a patient with bone marrow hypoplasia.
Journal
World Journal of Gastroenterology : Wjg
Author(s)
Bethlen S., Chandrikakumari K., de Leval L., Giot J.B., Mukeba D., Leonard P., Frippiat F., Meuris C., Delwaide J., Moutschen M.
ISSN
1007-9327[print], 1007-9327[linking]
Publication state
Published
Issued date
2008
Volume
14
Number
26
Pages
4238-4240
Language
english
Abstract
Chronic hepatitis C virus (HCV) infection is associated with multifarious extra-hepatic manifestations; the most described and discussed being mixed cryoglobulinemia which is strongly related to B-cell lymphoproliferative disorders (LPDs). We present a case of chronic HCV infection and mixed cryoglobulinemia, with minimal liver involvement. The case is a 53-year-old patient who was diagnosed as having bone marrow hypoplasia at the age of three. She received several blood transfusions to normalize her haemoglobin. At the age of 31, she was diagnosed with rheumatoid arthritis on account of her diffuse joint pain and inflammation, elevated rheumatoid factor (RF) and Raynaud's phenomenon. Twenty years later, monoclonal gammopathy of IgG Lambda (one year later, changed to IgM Kappa) was detected during a routine examination. A bone marrow biopsy showed hypoplasia, Kappa positive B-lymphocytes and low-grade malignant lymphoma cells. PCR of the bone marrow aspirate was not contributory. No treatment was initiated owing to her poor bone marrow function and she is under regular follow-up.
Keywords
Bone Marrow/pathology, Bone Marrow Diseases/complications, Cryoglobulinemia/etiology, Female, Hepatitis C, Chronic/complications, Humans, Middle Aged
Pubmed
Create date
27/10/2010 8:42
Last modification date
20/08/2019 15:15
Usage data