Detection rate of recurrent medullary thyroid carcinoma using fluorine-18 dihydroxyphenylalanine positron emission tomography: a meta-analysis.

Details

Serval ID
serval:BIB_AAF6F1BE348E
Type
Article: article from journal or magazin.
Collection
Publications
Title
Detection rate of recurrent medullary thyroid carcinoma using fluorine-18 dihydroxyphenylalanine positron emission tomography: a meta-analysis.
Journal
Academic radiology
Author(s)
Treglia G., Cocciolillo F., Di Nardo F., Poscia A., de Waure C., Giordano A., Rufini V.
ISSN
1878-4046 (Electronic)
ISSN-L
1076-6332
Publication state
Published
Issued date
10/2012
Peer-reviewed
Oui
Volume
19
Number
10
Pages
1290-1299
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis
Publication Status: ppublish
Abstract
The aim of this study was to perform a meta-analysis of published data about the diagnostic performance of (18)F-dihydroxyphenylalanine (DOPA) positron emission tomography (PET) or PET/computed tomography (CT) in detecting recurrent medullary thyroid carcinoma (MTC).
A comprehensive literature search of studies indexed in the PubMed/MEDLINE, Scopus, and Embase databases through January 2012 and regarding (18)F-DOPA PET or PET/CT in patients with suspected recurrent MTC was carried out. Pooled detection rates (DR) in per patient and per lesion analyses were calculated. A subanalysis considering serum levels of calcitonin and carcinoembryonic antigen, device used, and carbidopa pretreatment was also performed.
Eight studies including 146 patients with suspected recurrent MTC were included. The DRs of (18)F-DOPA PET and PET/CT in per patient and per lesion analyses were 66% and 71%, respectively. DRs significantly increased in patients with serum calcitonin ≥1000 ng/L (86%) and calcitonin doubling times <24 months (86%).
Fluorine-18-DOPA PET and PET/CT may be useful functional imaging methods in detecting recurrent MTC. The DR of recurrent MTC using these imaging methods increases in patients with higher calcitonin levels and lower calcitonin doubling times.

Keywords
Carcinoma, Neuroendocrine, Dihydroxyphenylalanine/analogs & derivatives, Humans, Neoplasm Recurrence, Local/diagnostic imaging, Neoplasm Recurrence, Local/epidemiology, Positron-Emission Tomography/statistics & numerical data, Prevalence, Radiopharmaceuticals, Reproducibility of Results, Risk Factors, Sensitivity and Specificity, Thyroid Neoplasms/diagnostic imaging, Thyroid Neoplasms/epidemiology
Pubmed
Web of science
Create date
20/08/2017 20:55
Last modification date
20/08/2019 15:14
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