Iodide transport: implications for health and disease.

Details

Serval ID
serval:BIB_AAF5620C080E
Type
Article: article from journal or magazin.
Collection
Publications
Title
Iodide transport: implications for health and disease.
Journal
International journal of pediatric endocrinology
Author(s)
Pesce L., Kopp P.
ISSN
1687-9848 (Print)
ISSN-L
1687-9848
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
2014
Number
1
Pages
8
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Disorders of the thyroid gland are among the most common conditions diagnosed and managed by pediatric endocrinologists. Thyroid hormone synthesis depends on normal iodide transport and knowledge of its regulation is fundamental to understand the etiology and management of congenital and acquired thyroid conditions such as hypothyroidism and hyperthyroidism. The ability of the thyroid to concentrate iodine is also widely used as a tool for the diagnosis of thyroid diseases and in the management and follow up of the most common type of endocrine cancers: papillary and follicular thyroid cancer. More recently, the regulation of iodide transport has also been the center of attention to improve the management of poorly differentiated thyroid cancer. Iodine deficiency disorders (goiter, impaired mental development) due to insufficient nutritional intake remain a universal public health problem. Thyroid function can also be influenced by medications that contain iodide or interfere with iodide metabolism such as iodinated contrast agents, povidone, lithium and amiodarone. In addition, some environmental pollutants such as perchlorate, thiocyanate and nitrates may affect iodide transport. Furthermore, nuclear accidents increase the risk of developing thyroid cancer and the therapy used to prevent exposure to these isotopes relies on the ability of the thyroid to concentrate iodine. The array of disorders involving iodide transport affect individuals during the whole life span and, if undiagnosed or improperly managed, they can have a profound impact on growth, metabolism, cognitive development and quality of life.
Keywords
Hyperthyroidism, Hypothyroidism, Iodide transport, Iodine, Iodine deficiency, Radioactive iodine, Thyroid, Thyroid cancer, Thyroid hormones
Pubmed
Open Access
Yes
Create date
27/12/2020 22:43
Last modification date
28/12/2020 6:26
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