Clinical significance of incidental focal colorectal (18)F-fluorodeoxyglucose uptake: our experience and a review of the literature.

Details

Serval ID
serval:BIB_AAECEFB75FC6
Type
Article: article from journal or magazin.
Collection
Publications
Title
Clinical significance of incidental focal colorectal (18)F-fluorodeoxyglucose uptake: our experience and a review of the literature.
Journal
Colorectal disease
Author(s)
Treglia G., Calcagni M.L., Rufini V., Leccisotti L., Meduri G.M., Spitilli M.G., Dambra D.P., De Gaetano A.M., Giordano A.
ISSN
1463-1318 (Electronic)
ISSN-L
1462-8910
Publication state
Published
Issued date
02/2012
Peer-reviewed
Oui
Volume
14
Number
2
Pages
174-180
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The aims of the present study were: (i) to evaluate the focal incidental colorectal uptake of (18)F-fluorodeoxyglucose ([(18)F]FDG) and to correlate it with colonoscopy and histological findings; (ii) to evaluate the relationship between the presence/absence of neoplastic disease and clinical data and the anatomical site of [(18)F]FDG uptake; and (iii) to compare our results with those reported for incidental colorectal uptake of [(18)F]FDG in the literature and those obtained from various screening programmes for colorectal cancer.
The database of 6000 patients referred for [(18)F]FDG positron emission tomography/computed tomography (PET-CT) to our centre was retrospectively reviewed for incidental colorectal uptake of [(18)F]FDG. Patients with focal uptake were selected and the aetiology of PET findings was verified with a subsequent colonoscopy and histopathological analysis when available.
Incidental colorectal uptake of [(18)F]FDG was seen in 144 (2.4%) patients, of whom 64 (1.1%) had focal uptake; 48 out of these 64 patients underwent colonoscopy, which showed malignant tumours in 12 (25%), premalignant lesions in 19 (40%), non-neoplastic lesions in six (12%) and lesions not confirmed by colonoscopy in 11 (23%). Our data agreed with previously published data. Statistical analysis did not show any significant relationship between the presence/absence of neoplastic disease and patient sex or age, type of primary disease and anatomical site of [(18)F]FDG uptake. Comparing our data with various screening programmes, a significant difference was found only with series in which colonoscopy was performed in patients at high risk for colorectal cancer.
Focal incidental colorectal uptake of [(18)F]FDG is observed in about 1% of PET/CT studies and carries a high risk of neoplastic disease. A PET-CT report should suggest colonoscopy when abnormal findings are reported.

Keywords
Adenocarcinoma/diagnostic imaging, Adenocarcinoma/pathology, Adenoma/diagnostic imaging, Adenoma/pathology, Adult, Aged, Aged, 80 and over, Analysis of Variance, Chi-Square Distribution, Colonic Neoplasms/diagnostic imaging, Colonic Neoplasms/pathology, Colonic Polyps/diagnostic imaging, Colonic Polyps/pathology, Colonoscopy, Diverticulitis, Colonic/diagnostic imaging, Female, Fluorodeoxyglucose F18, Humans, Incidental Findings, Leiomyosarcoma/diagnostic imaging, Leiomyosarcoma/pathology, Lymphoma/diagnostic imaging, Lymphoma/pathology, Male, Middle Aged, Multimodal Imaging, Positron-Emission Tomography, Radiopharmaceuticals, Rectal Neoplasms/diagnostic imaging, Rectal Neoplasms/pathology, Retrospective Studies, Tomography, X-Ray Computed
Pubmed
Web of science
Create date
20/08/2017 21:17
Last modification date
20/08/2019 15:14
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