Biomarker analysis of stored blood products: emphasis on pre-analytical issues.

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Serval ID
serval:BIB_AADFD6BAE81D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Biomarker analysis of stored blood products: emphasis on pre-analytical issues.
Journal
International Journal of Molecular Sciences
Author(s)
Delobel J., Rubin O., Prudent M., Crettaz D., Tissot J.D., Lion N.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Publication state
Published
Issued date
2010
Volume
11
Number
11
Pages
4601-4617
Language
english
Notes
Publication types: Journal Article
Review
Abstract
Millions of blood products are transfused every year; many lives are thus directly concerned by transfusion. The three main labile blood products used in transfusion are erythrocyte concentrates, platelet concentrates and fresh frozen plasma. Each of these products has to be stored according to its particular components. However, during storage, modifications or degradation of those components may occur, and are known as storage lesions. Thus, biomarker discovery of in vivo blood aging as well as in vitro labile blood products storage lesions is of high interest for the transfusion medicine community. Pre-analytical issues are of major importance in analyzing the various blood products during storage conditions as well as according to various protocols that are currently used in blood banks for their preparations. This paper will review key elements that have to be taken into account in the context of proteomic-based biomarker discovery applied to blood banking.
Keywords
Labile Blood Products, Aging And Storage Lesions, Biomarkers, Pre-Analytics, Proteomics, 2-Dimensional Gel-Electrophoresis, Flight-Mass-Spectrometry, Platelet Storage Lesion, Senescent Cell Antigen, Seldi-TOF MS, Proteomic Analysis, Protein Quantitation, Clinical Proteomics, Extensive Analysis, Glycoprotein-IB
Pubmed
Web of science
Open Access
Yes
Create date
20/12/2010 10:33
Last modification date
20/08/2019 15:14
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