Variability in immunophenotype in diffuse large B-cell lymphoma and its clinical relevance.

Details

Serval ID
serval:BIB_AABFABDC5428
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Variability in immunophenotype in diffuse large B-cell lymphoma and its clinical relevance.
Journal
Histopathology
Author(s)
de Leval L., Harris N.L.
ISSN
0309-0167[print], 0309-0167[linking]
Publication state
Published
Issued date
2003
Volume
43
Number
6
Pages
509-528
Language
english
Abstract
Diffuse large B-cell lymphoma (DLBCL), the single largest category of lymphoma, is a clinically and biologically heterogeneous disease entity. Clinically, patients differ in their mode of presentation and respond variably to therapy. A combination of clinical parameters can be used to predict the patient's response to therapy and survival. The pathological variability of DLBCL is expressed in morphology, immunophenotype, cytogenetic and molecular genetic features. Numerous markers detectable by immunohistochemistry and linked to different aspects of tumour biology have been studied in DLBCL, including lineage-associated and immune markers, proliferation and apoptosis markers, cell adhesion molecules, and more recently stage-specific markers of B-cell differentiation. This review summarizes these studies in regard to their clinical significance and in the light of recent advances in our understanding of the molecular pathology and histogenesis of DLBCL.
Keywords
Apoptosis/immunology, Cell Differentiation/immunology, Cell Division/immunology, Humans, Immunophenotyping, Lymphoma, B-Cell/immunology, Lymphoma, B-Cell/pathology, Lymphoma, Large B-Cell, Diffuse/immunology, Lymphoma, Large B-Cell, Diffuse/pathology
Pubmed
Create date
28/10/2010 9:53
Last modification date
20/08/2019 15:14
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