Feasibility of non-invasive pressure support ventilation in infants with respiratory failure after extubation: a pilot study.

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Serval ID
serval:BIB_AAA2D47CD126
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Feasibility of non-invasive pressure support ventilation in infants with respiratory failure after extubation: a pilot study.
Journal
Intensive Care Medicine
Author(s)
Stucki Pascal, Perez Marie-Hélène, Scalfaro Pietro, de Halleux Quentin, Vermeulen François, Cotting Jacques
ISSN
1432-1238[electronic]
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
35
Number
9
Pages
1623-1627
Language
english
Abstract
OBJECTIVE: To evaluate the feasibility and effects of non-invasive pressure support ventilation (NIV) on the breathing pattern in infants developing respiratory failure after extubation. DESIGN: Prospective pilot clinical study; each patient served as their own control. SETTING: A nine-bed paediatric intensive care unit of a tertiary university hospital. PATIENTS: Six patients (median age 5 months, range 0.5-7 months; median weight 4.2 kg, range 3.8-5.1 kg) who developed respiratory failure after extubation. INTERVENTIONS: After a period of spontaneous breathing (SB), children who developed respiratory failure were treated with NIV. MEASUREMENTS AND RESULTS: Measurements included clinical dyspnoea score (DS), blood gases and oesophageal pressure recordings, which were analysed for respiratory rate (RR), oesophageal inspiratory pressure swing (dPes) and oesophageal pressure-time product (PTPes). All data were collected during both periods (SB and NIV). When comparing NIV with SB, DS was reduced by 44% (P < 0.001), RR by 32% (P < 0.001), dPes by 45% (P < 0.01) and PTPes by 57% (P < 0.001). A non-significant trend for decrease in PaCO(2) was observed. CONCLUSION: In these infants, non-invasive pressure support ventilation with turbine flow generator induced a reduction of breathing frequency, dPes and PTPes, indicating reduced load of the inspiratory muscles. NIV can be used with some benefits in infants with respiratory failure after extubation.
Keywords
Continuous Positive Airway Pressure, Feasibility Studies, Female, Humans, Infant, Infant, Newborn, Intubation, Intratracheal, Male, Pilot Projects, Prospective Studies, Respiratory Insufficiency/therapy
Pubmed
Web of science
Open Access
Yes
Create date
14/01/2010 13:19
Last modification date
01/10/2019 6:19
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