Multimodal imaging in type 2 idiopathic macular telangiectasia.

Details

Serval ID
serval:BIB_AA7E95E10D55
Type
Article: article from journal or magazin.
Collection
Publications
Title
Multimodal imaging in type 2 idiopathic macular telangiectasia.
Journal
Retina
Author(s)
Sallo F.B., Leung I., Clemons T.E., Peto T., Bird A.C., Pauleikhoff D.
ISSN
1539-2864 (Electronic)
ISSN-L
0275-004X
Publication state
Published
Issued date
04/2015
Peer-reviewed
Oui
Volume
35
Number
4
Pages
742-749
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Macular telangiectasia Type 2 is a bilateral, progressive potentially blinding retinal disease characterized by both vascular and neurodegenerative signs that have been documented using different imaging techniques. The correlation between macular telangiectasia Type 2 signs from various imaging modalities is unknown. Our aim was to investigate the relationship of various macular telangiectasia Type 2 signs using fundus fluorescein angiography, optical coherence tomography and dual-wavelength autofluorescence images.
Participants were selected from the macular telangiectasia Type 2 Natural History Observation Study, based on a confirmed diagnosis and the availability of images. Signs in fundus fluorescein angiography, dual-wavelength autofluorescence, and optical coherence tomography images were graded according to standardized categories, and agreement among the multimodel imaging was assessed statistically.
One hundred and ninety-one eyes of 96 patients were examined. Significant correlations were found between early and late fundus fluorescein angiography (ρ = 0.82, P < 0.0001), luteal pigment loss and early/late fundus fluorescein angiography signs (ρ = 0.52, P < 0.0001 and ρ = 0.62, P < 0.0001, respectively), inner and outer segment break length and pigment loss (Class 1 vs. 2/3, P < 0.0001; Class 2 vs. 3, P = 0.04). Correlation between pigment loss and retinal spaces/atrophic retinal restructuring was fair (κ = 0.25-0.33). Bilateral symmetry was slight to substantial (κ = 0.18-0.62).
Our data demonstrate the relative extent of neurodegenerative and vascular signs; it may be useful for designing systems for staging disease severity using multimodal imaging and may also provide clues to the pathogenesis of the disease.
Keywords
Adult, Aged, Aged, 80 and over, Female, Fluorescein Angiography, Humans, Male, Middle Aged, Multimodal Imaging, Optical Imaging, Phenotype, Prospective Studies, Retinal Telangiectasis/diagnosis, Retinal Vessels/pathology, Tomography, Optical Coherence
Pubmed
Web of science
Create date
26/09/2024 20:18
Last modification date
27/09/2024 16:46
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