Herpesvirus saimiri Tip gene causes T-cell lymphomas in transgenic mice.

Details

Serval ID
serval:BIB_AA7802CF72E9
Type
Article: article from journal or magazin.
Collection
Publications
Title
Herpesvirus saimiri Tip gene causes T-cell lymphomas in transgenic mice.
Journal
DNA and Cell Biology
Author(s)
Wehner L.E., Schröder N., Kamino K., Friedrich U., Biesinger B., Rüther U.
ISSN
1044-5498
Publication state
Published
Issued date
2001
Peer-reviewed
Oui
Volume
20
Number
2
Pages
81-88
Language
english
Abstract
New World primates develop T-cell lymphomas on infection with Herpesvirus saimiri. To investigate the oncogenic potential of the Tip gene of Herpesvirus saimiri strain C488, we tried to establish transgenic mice that should express Tip under control of a constitutive promoter. Although transgene-positive embryos were found, lines could not be established. However, using a system in which the transgene has to be activated by a Cre recombinase-mediated deletion, we were able to obtain several Tip transgenic lines. At high expression levels, the mice developed T-cell lymphomas. Thus, Tip can induce lymphomas and is therefore very likely responsible for the oncogenicity of Herpesvirus saimiri.
Keywords
Animals, Crosses, Genetic, Embryonic and Fetal Development/genetics, Genes, Viral, Herpesvirus 2, Saimiriine/genetics, Herpesvirus 2, Saimiriine/pathogenicity, Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism, Lymphoma, T-Cell/genetics, Lymphoma, T-Cell/mortality, Mice, Mice, Inbred C3H, Mice, Inbred C57BL, Mice, Transgenic/genetics, Mice, Transgenic/virology, Phosphoproteins/biosynthesis, Phosphoproteins/genetics, Survival Analysis, Viral Proteins/biosynthesis, Viral Proteins/genetics, Viral Structural Proteins/genetics
Pubmed
Web of science
Create date
08/10/2008 10:01
Last modification date
20/08/2019 15:14
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