Calcineurin-Mediated Regulation of Hyphal Growth, Septation, and Virulence in Aspergillus fumigatus.

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Serval ID
serval:BIB_AA5E5228B562
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Calcineurin-Mediated Regulation of Hyphal Growth, Septation, and Virulence in Aspergillus fumigatus.
Journal
Mycopathologia
Author(s)
Juvvadi P.R., Lamoth F., Steinbach W.J.
ISSN
1573-0832 (Electronic)
ISSN-L
0301-486X
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
178
Number
5-6
Pages
341-348
Language
english
Notes
Publication types: Journal Article
Abstract
Calcineurin is a heterodimeric protein phosphatase complex composed of catalytic (CnaA) and regulatory (CnaB) subunits and plays diverse roles in regulating fungal stress responses, morphogenesis, and pathogenesis. Fungal pathogens utilize the calcineurin pathway to survive in the host environment and cause life-threatening infections. The immunosuppressive calcineurin inhibitors (FK506 and cyclosporine A) are active against fungi, making calcineurin a promising antifungal drug target. Here, we review novel findings on calcineurin localization and functions in Aspergillus fumigatus hyphal growth and septum formation through regulation of proteins involved in cell wall biosynthesis. Extensive mutational analysis in the functional domains of A. fumigatus CnaA has led to an understanding of the relevance of these domains for the localization and function of CnaA at the hyphal septum. An evolutionarily conserved novel mode of calcineurin regulation by phosphorylation in filamentous fungi was found to be responsible for virulence in A. fumigatus. This finding of a filamentous fungal-specific mechanism controlling hyphal growth and virulence represents a potential target for antifungal therapy.
Pubmed
Web of science
Create date
27/12/2014 9:16
Last modification date
20/08/2019 15:14
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