Evaluation of corneal stromal demarcation line depth following standard and a modified-accelerated collagen cross-linking protocol.

Details

Serval ID
serval:BIB_AA466954F6C7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Evaluation of corneal stromal demarcation line depth following standard and a modified-accelerated collagen cross-linking protocol.
Journal
American journal of ophthalmology
Author(s)
Kymionis G.D., Tsoulnaras K.I., Grentzelos M.A., Liakopoulos D.A., Tsakalis N.G., Blazaki S.V., Paraskevopoulos T.A., Tsilimbaris M.K.
ISSN
1879-1891 (Electronic)
ISSN-L
0002-9394
Publication state
Published
Issued date
10/2014
Peer-reviewed
Oui
Volume
158
Number
4
Pages
671-675.e1
Language
english
Notes
Publication types: Comparative Study ; Evaluation Studies ; Journal Article
Publication Status: ppublish
Abstract
To compare the corneal stromal demarcation line depth using anterior segment optical coherence tomography (AS-OCT) after corneal collagen cross-linking (CXL) using 2 different treatment protocols: the standard Dresden protocol (30 minutes with 3 mW/cm(2)) and a modified-accelerated protocol (14 minutes with 9 mW/cm(2)).
Prospective, comparative study.
Forty-three keratoconic patients (52 eyes) were enrolled. All patients underwent CXL using the same high-intensity ultraviolet-A (UV-A) irradiation device. Twenty-six eyes were treated for 30 minutes with 3 mW/cm(2) according to the standard Dresden protocol (Group 1), while 26 eyes were treated with a novel modified-accelerated CXL protocol for 14 minutes with 9 mW/cm(2) of UV-A irradiation intensity (Group 2). One month postoperatively, corneal stromal demarcation line depth was measured by 2 independent observers using AS-OCT.
Corneal stromal demarcation line depth was assessed with no significant difference between observer measurements for both groups (P = .676 for Group 1 and P = .566 for Group 2). Mean corneal stromal demarcation line depth was 337.00 ± 46.46 μm for Group 1 and 322.91 ± 48.28 μm for Group 2. There was no statistically significant difference (P = .243) in the corneal stromal demarcation line depth between the 2 groups.
Corneal stromal demarcation line depth using UV-A with 3 mW/cm(2) for 30 minutes and 9 mW/cm(2) for 14 minutes was similar. A modified-accelerated protocol of 14 minutes of CXL provided the same treatment depth as the classic Dresden protocol.
Keywords
Adolescent, Adult, Collagen/metabolism, Corneal Pachymetry, Corneal Stroma/metabolism, Corneal Stroma/pathology, Cross-Linking Reagents/therapeutic use, Female, Humans, Keratoconus/drug therapy, Keratoconus/metabolism, Keratoconus/pathology, Male, Middle Aged, Photosensitizing Agents/therapeutic use, Prospective Studies, Riboflavin/therapeutic use, Tomography, Optical Coherence, Ultraviolet Rays, Young Adult
Pubmed
Web of science
Create date
30/09/2019 16:18
Last modification date
06/10/2019 5:26
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