Dose-response relationships following oral administration of DuP 753 to normal humans

Details

Ressource 1Download: serval:BIB_AA35F97CAF0C.P001 (796.69 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_AA35F97CAF0C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Dose-response relationships following oral administration of DuP 753 to normal humans
Journal
American Journal of Hypertension
Author(s)
Christen Y., Waeber B., Nussberger J., Lee R. J., Timmermans P. B., Brunner H. R.
ISSN
0895-7061 (Print)
Publication state
Published
Issued date
04/1991
Volume
4
Number
4 Pt 2
Pages
350S-353S
Language
english
Notes
Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr
Abstract
We assessed the inhibitory effect of DuP 753, an orally active angiotensin II receptor antagonist, on the pressor action of exogenous angiotensin I and II in healthy volunteers. In a single dose study, doses of 2.5, 5, 10, 20, and 40 mg of DuP 753 or placebo were tested serially at one week intervals. In the multiple dose study, the administration of placebo or DuP 735 (5, 10, 20, or 40 mg, per os once daily) for eight consecutive days was evaluated. The blood pressure response to angiotensin I and II was inhibited in a dose-dependent fashion with a blocking effect still present 24 h post drug. DuP 753 also induced a dose-dependent compensatory rise in plasma renin. This new compound was well tolerated by these normal volunteers. Thus, DuP 753 appears to be a well tolerated, orally active, potent and long-lasting antagonist of angiotensin II in humans.
Keywords
Administration, Oral Adult Angiotensin II/*antagonists & inhibitors Blood Pressure/drug effects Dose-Response Relationship, Drug Drug Administration Schedule Humans Imidazoles/pharmacokinetics/*pharmacology Losartan Male Reference Values Renin-Angiotensin System/drug effects Single-Blind Method Tetrazoles/pharmacokinetics/*pharmacology
Pubmed
Web of science
Open Access
Yes
Create date
05/03/2008 16:39
Last modification date
01/10/2019 6:19
Usage data