Estimating and explaining the effect of education and income on head and neck cancer risk : INHANCE consortium pooled analysis of 31 case-control studies from 27 countries

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Serval ID
serval:BIB_A9F924ADA31C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Estimating and explaining the effect of education and income on head and neck cancer risk : INHANCE consortium pooled analysis of 31 case-control studies from 27 countries
Journal
International Journal of Cancer. Journal International Du Cancer
Author(s)
Conway D.I., Brenner D.R., McMahon A.D., Macpherson L.M., Agudo A., Ahrens W., Bosetti C., Brenner H., Castellsague X., Chen C., Curado M.P., Curioni O.A., Maso L.D., Daudt A.W., de Gois Filho J.F., D'Souza G., Edefonti V., Fabianova E., Fernandez L., Franceschi S., Gillison M., Hayes R.B., Healy C.M., Herrero R., Holcatova I., Jayaprakash V., Kelsey K., Kjaerheim K., Koifman S., Vecchia C.L., Lagiou P., Lazarus P., Levi F., Lissowska J., Luce D., Macfarlane T.V., Mates D., Matos E., McClean M., Menezes A.M., Menvielle G., Merletti F., Morgenstern H., Moysich K., Müller H., Muscat J., Olshan A.F., Purdue M.P., Ramroth H., Richiardi L., Rudnai P., Schantz S., Schwartz S.M., Shangina O., Simonato L., Smith E., Stucker I., Sturgis E.M., Szeszenia-Dabrowska N., Talamini R., Thomson P., Vaughan T.L., Wei Q., Winn D.M., Wunsch-Filho V., Yu G.P., Zhang Z.F., Zheng T., Znaor A., Boffetta P., Chuang S.C., Amy Lee Y.C., Hashibe M., Brennan P.
ISSN
1097-0215 (Electronic)
ISSN-L
0020-7136
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
136
Number
5
Pages
1125-1139
Language
english
Notes
IUMSP2015/03
Abstract
Low socioeconomic status has been reported to be associated with head and neck cancer risk. However, previous studies have been too small to examine the associations by cancer subsite, age, sex, global region, and calendar time, and to explain the association in terms of behavioural risk factors. Individual participant data of 23,964 cases with head and neck cancer and 31,954 controls from 31 studies in 27 countries pooled with random effects models. Overall, low education was associated with an increased risk of head and neck cancer (OR = 2·50; 95%CI 2·02- 3·09). Overall one-third of the increased risk was not explained by differences in the distribution of cigarette smoking and alcohol behaviours; and it remained elevated among never users of tobacco and non-drinkers (OR = 1·61; 95%CI 1·13 - 2·31). More of the estimated education effect was not explained by cigarette smoking and alcohol behaviours: in women than in men, in older than younger groups, in the oropharynx than in other sites, in South/Central America than in Europe/North America, and was strongest in countries with greater income inequality. Similar findings were observed for the estimated effect of low vs high household income. The lowest levels of income and educational attainment were associated with more than 2-fold increased risk of head and neck cancer, which is not entirely explained by differences in the distributions of behavioural risk factors for these cancers, and which varies across cancer sites, sexes, countries, and country income inequality levels. © 2014 Wiley Periodicals, Inc.
Pubmed
Web of science
Open Access
Yes
Create date
14/07/2014 9:01
Last modification date
20/08/2019 15:14
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