Arterial stiffness and enlargement in mild-to-moderate chronic kidney disease

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Ressource 1Download: Briet arterial stiffness mild-moderate CKD - NephroTest cohort Kidney Int 2006.pdf (138.42 [Ko])
State: Serval
Version: Final published version
License: Not specified
Serval ID
serval:BIB_A9C4E6DEA441
Type
Article: article from journal or magazin.
Collection
Publications
Title
Arterial stiffness and enlargement in mild-to-moderate chronic kidney disease
Journal
Kidney International
Author(s)
Briet M., Bozec E., Laurent S., Fassot C., London G. M., Jacquot C., Froissart M., Houillier P., Boutouyrie P.
ISSN
0085-2538
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
69
Number
2
Pages
350-7
Language
english
Notes
Briet, M
Bozec, E
Laurent, S
Fassot, C
London, G M
Jacquot, C
Froissart, M
Houillier, P
Boutouyrie, P
eng
Research Support, Non-U.S. Gov't
2006/01/13 09:00
Kidney Int. 2006 Jan;69(2):350-7.
Abstract
Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular morbidity and mortality. Arterial stiffness and remodeling have been well documented in patients with end-stage renal disease, but little is known about arterial phenotype in CKD patients with moderate reduction in glomerular filtration rate (GFR). In total, 95 patients (58+/-15 years, mean+/-s.d.) with CKD and GFR measured by renal clearance of (51)Cr-ethylenediaminetetraacetate were compared to 121 hypertensive patients without CKD (59+/-11 years), and 57 normotensive subjects (56+/-6 years). Common carotid artery diameter, intima-media thickness (IMT), distensibility, and Young's elastic modulus were noninvasively determined with a high-definition echotracking system. Patients with CKD had a significantly larger carotid internal diameter than in hypertensives and normotensives (6.32+/-1.05, 5.84+/-0.74, and 5.50+/-0.64 m x 10(-3), respectively; P<0.001), resulting in 25% and 11% increases in circumferential wall stress, respectively, since no significant difference in IMT was observed. Carotid distensibility and elastic modulus did not significantly differ between CKD and hypertensives; normotensives had significantly higher distensibility and lower elastic modulus than CKD and hypertensive patients. Carotid-femoral pulse wave velocity was significantly higher in CKD patients than in hypertensives and normotensives. In multivariate analyses either involving the entire population or restricted to CKD patients, GFR was independently and strongly related to carotid diameter and elastic modulus. Arterial enlargement and increased arterial stiffness occur in parallel with the decline in renal function in patients with mild-to-moderate CKD.
Keywords
Adult, Aged, Aorta/pathology/physiopathology, Carotid Arteries/*pathology/physiopathology, Chronic Disease, Elasticity, Female, Glomerular Filtration Rate, Humans, Hypertrophy, Kidney/physiopathology, Kidney Diseases/*pathology/physiopathology, Male, Middle Aged, Multivariate Analysis
Open Access
Yes
Create date
03/03/2016 17:49
Last modification date
22/05/2019 6:26
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