Clinical Experience with Immune Monitoring for Cytomegalovirus in Solid-Organ Transplant Recipients.

Details

Serval ID
serval:BIB_A9B91DE15CF2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Clinical Experience with Immune Monitoring for Cytomegalovirus in Solid-Organ Transplant Recipients.
Journal
Current Infectious Disease Reports
Author(s)
Manuel O.
ISSN
1523-3847 (Print)
ISSN-L
1523-3847
Publication state
Published
Issued date
2013
Language
english
Notes
Publication types: ARTICLE
Publication Status: aheadofprint
Abstract
Novel strategies are needed to further reduce the burden of cytomegalovirus (CMV) disease in solid-organ transplant (SOT) recipients. Measurement of the specific cell-mediated immunity against CMV can identify the actual risk for the development of CMV disease in a given patient. Thus, immune monitoring is an attractive strategy for individualizing the management of CMV after transplantation. A growing number of observational studies on immune monitoring for CMV have been published over recent years, although there is a lack of data coming from interventional trials. In high-risk patients, measurement of CMV-specific T-cell responses appropriately stratifies the risk of CMV disease after discontinuation of antiviral prophylaxis. Immune monitoring may also help to identify patients followed by the preemptive approach at low risk for progression to CMV disease. Pretransplant assessment of cell-mediated immunity in seropositive patients may predict the development of posttransplant CMV infection. Overall, these studies indicate that the use of cell-mediated immunity assays has the potential to improve the management of CMV disease in SOT recipients.
Pubmed
Create date
13/02/2015 18:13
Last modification date
24/01/2020 7:26
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