Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration.

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Serval ID
serval:BIB_A9B1A7211DAD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration.
Journal
Nature communications
Author(s)
Noordam R., Bos M.M., Wang H., Winkler T.W., Bentley A.R., Kilpeläinen T.O., de Vries P.S., Sung Y.J., Schwander K., Cade B.E., Manning A., Aschard H., Brown M.R., Chen H., Franceschini N., Musani S.K., Richard M., Vojinovic D., Aslibekyan S., Bartz T.M., de Las Fuentes L., Feitosa M., Horimoto A.R., Ilkov M., Kho M., Kraja A., Li C., Lim E., Liu Y., Mook-Kanamori D.O., Rankinen T., Tajuddin S.M., van der Spek A., Wang Z., Marten J., Laville V., Alver M., Evangelou E., Graff M.E., He M., Kühnel B., Lyytikäinen L.P., Marques-Vidal P., Nolte I.M., Palmer N.D., Rauramaa R., Shu X.O., Snieder H., Weiss S., Wen W., Yanek L.R., Adolfo C., Ballantyne C., Bielak L., Biermasz N.R., Boerwinkle E., Dimou N., Eiriksdottir G., Gao C., Gharib S.A., Gottlieb D.J., Haba-Rubio J., Harris T.B., Heikkinen S., Heinzer R., Hixson J.E., Homuth G., Ikram M.A., Komulainen P., Krieger J.E., Lee J., Liu J., Lohman K.K., Luik A.I., Mägi R., Martin L.W., Meitinger T., Metspalu A., Milaneschi Y., Nalls M.A., O'Connell J., Peters A., Peyser P., Raitakari O.T., Reiner A.P., Rensen PCN, Rice T.K., Rich S.S., Roenneberg T., Rotter J.I., Schreiner P.J., Shikany J., Sidney S.S., Sims M., Sitlani C.M., Sofer T., Strauch K., Swertz M.A., Taylor K.D., Uitterlinden A.G., van Duijn C.M., Völzke H., Waldenberger M., Wallance R.B., van Dijk K.W., Yu C., Zonderman A.B., Becker D.M., Elliott P., Esko T., Gieger C., Grabe H.J., Lakka T.A., Lehtimäki T., North K.E., Penninx BWJH, Vollenweider P., Wagenknecht L.E., Wu T., Xiang Y.B., Zheng W., Arnett D.K., Bouchard C., Evans M.K., Gudnason V., Kardia S., Kelly T.N., Kritchevsky S.B., Loos RJF, Pereira A.C., Province M., Psaty B.M., Rotimi C., Zhu X., Amin N., Cupples L.A., Fornage M., Fox E.F., Guo X., Gauderman W.J., Rice K., Kooperberg C., Munroe P.B., Liu C.T., Morrison A.C., Rao D.C., van Heemst D., Redline S.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
12/11/2019
Peer-reviewed
Oui
Volume
10
Number
1
Pages
5121
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lipid loci have a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explain 4.25% of the variance in triglyceride level. Collectively, these findings contribute to our understanding of the biological mechanisms involved in sleep-associated adverse lipid profiles.
Pubmed
Web of science
Open Access
Yes
Create date
19/12/2019 10:45
Last modification date
28/07/2020 5:21
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