Spinal cord lesion after long-term intrathecal clonidine and bupivacaine treatment for the management of intractable pain

Details

Serval ID
serval:BIB_A92E8103EF4B
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Spinal cord lesion after long-term intrathecal clonidine and bupivacaine treatment for the management of intractable pain
Journal
Pain
Author(s)
Perren  F., Buchser  E., Chedel  D., Hirt  L., Maeder  P., Vingerhoets  F.
ISSN
0304-3959
Publication state
Published
Issued date
05/2004
Peer-reviewed
Oui
Volume
109
Number
1-2
Pages
189-94
Notes
Case Reports
Comparative Study
Perren, Fabienne
Buchser, Eric
Chedel, Dominique
Hirt, Lorenz
Maeder, Philippe
Vingerhoets, Francois
Netherlands
Pain
Pain. 2004 May;109(1-2):189-94. --- Old month value: May
Abstract
Long-term intrathecal drug administration using implanted pumps is increasingly used in the treatment of chronic refractory pain [Anderson and Burchiel 1999, Neurosurgery 44 (1999) 289; Krames 2002, Best Pract Res Clin Anaesthesiol 16 (2002) 619; Wallace 2002, Neurology 59 (2002) S18]. Extensive clinical experience over the last 15 years suggests that in selected cases the technique is safe, although infections, system malfunction and drug-related complications have been reported. In most cases, drug-related spinal cord injuries have resulted from the compression of a spinal inflammatory mass or abcess rather than from a direct neurotoxic effect. We report on a case of toxic spinal cord lesion occurring after more than 3 years of uneventful continuous infusion of a mixture of bupivacaine and clonidine.
Keywords
Analgesia, Epidural/methods Analgesics/*adverse effects/therapeutic use Bupivacaine/*adverse effects/therapeutic use Clonidine/*adverse effects/therapeutic use Humans Infusion Pumps, Implantable Longitudinal Studies Magnetic Resonance Imaging/methods Male Middle Aged Pain Measurement/drug effects Pain, Intractable/drug therapy Spinal Cord Injuries/*chemically induced/pathology Treatment Outcome
Pubmed
Web of science
Create date
11/04/2008 9:23
Last modification date
20/08/2019 16:13
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