Procalcitonin and C-reactive protein in pericardial fluid for postmortem diagnosis of sepsis.

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State: Public
Version: author
Serval ID
serval:BIB_A913A23515EF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Procalcitonin and C-reactive protein in pericardial fluid for postmortem diagnosis of sepsis.
Journal
International Journal of Legal Medicine
Author(s)
Schrag B., Iglesias K., Mangin P., Palmiere C.
ISSN
1437-1596 (Electronic)
ISSN-L
0937-9827
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
126
Number
4
Pages
567-572
Language
english
Notes
Publication types: Journal Article
Abstract
The aim of this study was to investigate the presence and concentrations of procalcitonin and C-reactive protein in pericardial fluid and compare these levels to those found in the postmortem serum obtained from the femoral blood. Two groups were formed, a sepsis-related fatalities group and a control group. Postmortem native CT scans, autopsies, histology, neuropathology and toxicology as well as other postmortem biochemistry investigations were performed in all cases. Pericardial fluid procalcitonin levels were significantly different between the cases of sepsis-related fatalities and those of the control group. Postmortem serum procalcitonin levels below the detection limit were also reflected in undetectable pericardial fluid levels. Similarly, a large increase in postmortem serum procalcitonin levels was reflected in a large increase of procalcitonin pericardial fluid levels. Based on these findings, pericardial fluid could be an alternative to postmortem serum for the determination of procalcitonin levels in cases where postmortem serum is not available and measurements of procalcitonin are required to circumstantiate the pathogenesis of death.
Pubmed
Web of science
Create date
22/07/2012 21:59
Last modification date
20/08/2019 16:13
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