Liver-derived ketone bodies are necessary for food anticipation.

Details

Serval ID
serval:BIB_A8F382921D7D
Type
Article: article from journal or magazin.
Collection
Publications
Title
Liver-derived ketone bodies are necessary for food anticipation.
Journal
Nature communications
Author(s)
Chavan R, Feillet C, Fonseca Costa SS, Delorme JE, Okabe T, Ripperger JA, Albrecht U
Publication state
Published
Issued date
03/02/2016
Language
english
Abstract
The circadian system has endowed animals with the ability to anticipate recurring food availability at particular times of day. As daily food anticipation (FA) is independent of the suprachiasmatic nuclei, the central pacemaker of the circadian system, questions arise of where FA signals originate and what role components of the circadian clock might play. Here we show that liver-specific deletion of Per2 in mice abolishes FA, an effect that is rescued by viral overexpression of Per2 in the liver. RNA sequencing indicates that Per2 regulates β-hydroxybutyrate (βOHB) production to induce FA leading to the conclusion that liver Per2 is important for this process. Unexpectedly, we show that FA originates in the liver and not in the brain. However, manifestation of FA involves processing of the liver-derived βOHB signal in the brain, indicating that the food-entrainable oscillator is not located in a single tissue but is of systemic nature.
Pubmed
Create date
07/04/2022 13:15
Last modification date
08/04/2022 5:36
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