Efficacy of a vancomycin solution to prevent bacteremia associated with an indwelling central venous catheter in neutropenic and non-neutropenic cancer patients
Details
Serval ID
serval:BIB_A8C11E3F5643
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Efficacy of a vancomycin solution to prevent bacteremia associated with an indwelling central venous catheter in neutropenic and non-neutropenic cancer patients
Journal
Medical and Pediatric Oncology
ISSN
0098-1532 (Print)
Publication state
Published
Issued date
03/1997
Volume
28
Number
3
Pages
196-200
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Mar
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Mar
Abstract
We evaluated the efficacy of a vancomycin solution in the prevention of bacteremia caused by vancomycin-sensitive organisms (VSO) in cancer patients with a tunneled central venous catheter (CVC). Eighty-three patients who had a single lumen CVC were randomized to use a heparin solution (25 U/ml) for daily catheter flush with (HepVan) or without (Hep) vancomycin, 25 mcg/ml. Febrile episodes were recorded, and central and peripheral blood cultures were drawn before beginning antibiotic therapy. Patients participated in follow-up to 16,677 catheter days (8,666 Hep and 8,011 HepVan), and 143 febrile episodes were recorded (82 Hep and 61 HepVan). Forty-four episodes of bacteremia occurred, 23 of them due to VSO (16 occurred in the Hep group and 7 in the HepVan group (P = 0.19). VSO bacteremia occurred in 14 neutropenic (absolute neutrophil count < 500 x 10(9)/l) episodes (7 Hep vs. 7 HepVan) and in 9 non-neutropenic episodes (9 Hep vs. O HepVan; P = 0.013). Vancomycin effectively prevented bacteremia by VSO in non-neutropenic patients, supporting the idea that intraluminal colonization of indwelling CVCs contributes to bacteremia only in these patients.
Keywords
Adolescent
Adult
Anti-Bacterial Agents/*administration & dosage
Anticoagulants/administration & dosage
Bacteremia/etiology/microbiology/*prevention & control
Catheterization, Central Venous/*adverse effects
Catheters, Indwelling/*adverse effects
Child
Child, Preschool
Double-Blind Method
Female
Heparin/administration & dosage
Humans
Male
Middle Aged
Neoplasms/*blood/therapy
Neutropenia/*complications
Prospective Studies
Vancomycin/*administration & dosage
Pubmed
Web of science
Create date
24/01/2008 21:10
Last modification date
20/08/2019 16:13