Oral and intravenous methadone use: some clinical and pharmacokinetic aspects.

Details

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State: Public
Version: author
Serval ID
serval:BIB_A8A466938836
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Oral and intravenous methadone use: some clinical and pharmacokinetic aspects.
Journal
Drug and Alcohol Dependence
Author(s)
Felder C., Uehlinger C., Baumann P., Powell K., Eap C.B.
ISSN
0376-8716 (Print)
ISSN-L
0376-8716
Publication state
Published
Issued date
1999
Peer-reviewed
Oui
Volume
55
Number
1-2
Pages
137-143
Language
english
Notes
Publication types: Clinical Trial ; Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
A sample of 15 patients participating in an injectable methadone trial and of 15 patients in an oral methadone maintenance treatment, who admitted injecting part or all of their methadone take-home doses, were compared to 20 patients in maintenance treatment who use methadone exclusively by mouth. The present study confirms the poorer general health, the higher levels of emotional, psychological or psychiatric problems, the higher use of illicit drugs, and the higher number of problems related to employment and support associated with the use of the intravenous mode of administration of methadone. As expected, due to the shunt of metabolism in the gut wall and of the liver first-pass effect, higher concentration to dose ratios of (R)-methadone, which is the active enantiomer, were measured in the intravenous group (23% increase). This difference reached an almost statistically significant value (P = 0.054). This raises the question whether the effect of a higher methadone dose could be unconsciously sought by some of the intravenous methadone users.
Keywords
Administration, Oral, Adult, Brief Psychiatric Rating Scale, Depressive Disorder/diagnosis, Depressive Disorder/etiology, Dose-Response Relationship, Drug, Employment, Female, Health Status, Heroin/administration & dosage, Heroin/pharmacology, Humans, Injections, Intravenous, Male, Methadone/administration & dosage, Methadone/adverse effects, Schizophrenia/diagnosis, Schizophrenia/etiology, Self Administration, Severity of Illness Index, Substance Withdrawal Syndrome/urine, Substance-Related Disorders/diagnosis, Substance-Related Disorders/psychology
Pubmed
Web of science
Create date
01/03/2013 12:12
Last modification date
20/08/2019 16:13
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