A method to quantitate the fractional extraction of rubidium-82 across the blood-brain barrier using positron emission tomography.
Details
Serval ID
serval:BIB_A895C10C463D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A method to quantitate the fractional extraction of rubidium-82 across the blood-brain barrier using positron emission tomography.
Journal
Journal of Cerebral Blood Flow and Metabolism
ISSN
0271-678X (Print)
ISSN-L
0271-678X
Publication state
Published
Issued date
1984
Volume
4
Number
4
Pages
523-534
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Previously, rubidium-82 and positron emission tomography (PET) have been used to assess qualitatively the integrity of the blood-brain barrier (BBB). In this report, a method is described to measure the fractional extraction of rubidium across the BBB using the constant intravenous infusion of rubidium-82. In addition, the continuous inhalation of oxygen-15-labelled carbon dioxide is needed to measure regional CBF, and it is also necessary to measure regional cerebral blood volume. The assumptions underlying the model are identified, and the impact of deviations from these assumptions is described. From radiation dose and statistical considerations, it is shown that for normal cerebral tissue and the PET scanner used in this study, the rubidium extraction fraction can be quantitated only for regions as large as a cerebral hemisphere. However, quantitation is also possible for smaller regions where the focal extraction of rubidium is increased.
Keywords
Blood-Brain Barrier, Carbon Dioxide/metabolism, Carbon Monoxide/metabolism, Cerebrovascular Circulation, Humans, Mathematics, Radioisotopes/diagnostic use, Respiration, Rubidium/diagnostic use, Statistics as Topic, Tomography, Emission-Computed/methods
Pubmed
Web of science
Create date
09/10/2011 17:36
Last modification date
20/08/2019 15:13