Clinical assessment of fluorescence cytoscopy during transurethral bladder resection in superficial bladder cancer.

Details

Ressource 1Download: serval:BIB_A88DF9D15917.P001 (385.07 [Ko])
State: Public
Version: author
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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_A88DF9D15917
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Clinical assessment of fluorescence cytoscopy during transurethral bladder resection in superficial bladder cancer.
Journal
Urological research
Author(s)
Jichlinski P., Wagnières G., Forrer M., Mizeret J., Guillou L., Oswald M., Schmidlin F., Graber P., Van den Bergh H., Leisinger H.J.
ISSN
0300-5623
Publication state
Published
Issued date
1997
Peer-reviewed
Oui
Volume
25 Suppl 1
Pages
S3-6
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
The prognosis of superficial bladder cancer in terms of recurrence and disease progression is related to bladder tumor multiplicity and the presence of concomitant "plane" tumors such as high-grade dysplasia and carcinoma in situ. This study in 33 patients aimed to demonstrate the role of fluorescence cystoscopy in transurethral resection of superficial bladder cancer. The method is based on the detection of protoporphyrin-IX-induced fluorescence in urothelial cancer cells by topical administration of 5-aminolevulinic acid. The sensitivity and the specificity of this procedure on apparently normal mucosa in superficial bladder cancer are estimated to be 82.9% and 81.3%, respectively. Thus, fluorescence cytoscopy is a simple and reliable method for mapping the bladder mucosa, especially in the case of multifocal bladder disease, and it facilitates the screening of occult dysplasia.
Keywords
Adult, Aged, Aged, 80 and over, Aminolevulinic Acid, Carcinoma, Transitional Cell, Cystoscopes, Cystoscopy, Evaluation Studies as Topic, Female, Fluorescence, Humans, Krypton, Male, Middle Aged, Photosensitizing Agents, Protoporphyrins, Sensitivity and Specificity, Urinary Bladder, Urinary Bladder Neoplasms, Urine, Xenon
Pubmed
Web of science
Open Access
Yes
Create date
21/01/2008 17:09
Last modification date
01/10/2019 7:19
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