Fatal tolperisone poisoning: Autopsy and toxicology findings in three suicide cases.

Details

Serval ID
serval:BIB_A83F23EB00EF
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Poster: Summary – with images – on one page of the results of a researche project. The summaries of the poster must be entered in "Abstract" and not "Poster".
Collection
Publications
Institution
Title
Fatal tolperisone poisoning: Autopsy and toxicology findings in three suicide cases.
Title of the conference
48th Annual Meeting of the International Association of Forensic Toxicologists
Author(s)
Sporkert F., Brunel C., Augsburger M.P., Mangin P.
Address
Bonn, Germany, August 29 - September 2, 2010
ISBN
2190-3441
Publication state
Published
Issued date
2011
Volume
77
Series
Toxichem Krimtech
Pages
247
Language
english
Abstract
Tolperisone (Mydocalm(®)) is a centrally acting muscle relaxant with few sedative side effects that is used for the treatment of chronic pain conditions. We describe three cases of suicidal tolperisone poisoning in three healthy young subjects in the years 2006, 2008 and 2009. In all cases, macroscopic and microscopic autopsy findings did not reveal the cause of death. Systematic toxicological analysis (STA) including immunological tests, screening for volatile substances and blood, urine and gastric content screening by GC-MS and HPLC-DAD demonstrated the presence of tolperisone in all cases. In addition to tolperisone, only the analgesics paracetamol (acetaminophen), ibuprofen and naproxen could be detected. The blood ethanol concentrations were all lower than 0.10g/kg. Tolperisone was extracted by liquid-liquid extraction using n-chlorobutane as the extraction solvent. The quantification was performed by GC-NPD analysis of blood, urine and gastric content. Tolperisone concentrations of 7.0mg/l, 14mg/l and 19mg/l were found in the blood of the deceased. In the absence of other autopsy findings, the deaths in these three cases were finally explained as a result of lethal tolperisone ingestion. To the best of our knowledge, these three cases are the first reported cases of suicidal tolperisone poisonings.
Create date
11/03/2011 18:33
Last modification date
20/08/2019 15:12
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