Single cell gene expression profiling reveals qualitatively distinct CD8 T cells elicited by different gene-based vaccines

Details

Serval ID
serval:BIB_A83A53047AEB
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Single cell gene expression profiling reveals qualitatively distinct CD8 T cells elicited by different gene-based vaccines
Title of the conference
Annual Congress SGAI-SSAI, Advances in immunology and allergology: from research to diagnosis and therapy
Author(s)
Flatz L., Roychoudhuri R., Honda M., Filali A., Goulet J.P., Kettaf N., Roederer M., Haddad E., Sekaly R.P., Nabel G.J.
Address
Lugano, Switzerland, March 17-18, 2011
ISBN
0344-5062
Publication state
Published
Issued date
2011
Volume
34
Series
Allergologie
Pages
81-81
Language
english
Notes
Meeting Abstract
Abstract
The CD8 T cell response generatedby gene-based vaccines is importantfor protective immunity againstmany infectious diseases but its complexityis incompletely understood.Here, we report that different vaccinesencoding HIV Env elicit qualitativelydistinct CD8 T cells that wereidentified by patterns of gene expressionin individual cells. Three alternativeprime-boost vector combinationsstimulated antigen-specific CD8 Tcell populations of similar magnitudeand function by intracellular cytokinestaining; however, single cell geneexpression profiling enabled the discriminationof distinct CM and EMCD8 cells elicited by the three vaccines.Two previously unrecognizedCD8 T cell subsets have been definedby their coexpression of Eomes,Cxcr3 and Ccr7; or Klrk1, Klrg1 andCcr5 in CM and EM cells respectively.
Web of science
Create date
04/04/2011 10:48
Last modification date
20/08/2019 15:12
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