OMA orthology in 2021: website overhaul, conserved isoforms, ancestral gene order and more.

Details

Serval ID
serval:BIB_A827EF929B38
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
OMA orthology in 2021: website overhaul, conserved isoforms, ancestral gene order and more.
Journal
Nucleic acids research
Author(s)
Altenhoff A.M., Train C.M., Gilbert K.J., Mediratta I., Mendes de Farias T., Moi D., Nevers Y., Radoykova H.S., Rossier V., Warwick Vesztrocy A., Glover N.M., Dessimoz C.
ISSN
1362-4962 (Electronic)
ISSN-L
0305-1048
Publication state
Published
Issued date
08/01/2021
Peer-reviewed
Oui
Volume
49
Number
D1
Pages
D373-D379
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
OMA is an established resource to elucidate evolutionary relationships among genes from currently 2326 genomes covering all domains of life. OMA provides pairwise and groupwise orthologs, functional annotations, local and global gene order conservation (synteny) information, among many other functions. This update paper describes the reorganisation of the database into gene-, group- and genome-centric pages. Other new and improved features are detailed, such as reporting of the evolutionarily best conserved isoforms of alternatively spliced genes, the inferred local order of ancestral genes, phylogenetic profiling, better cross-references, fast genome mapping, semantic data sharing via RDF, as well as a special coronavirus OMA with 119 viruses from the Nidovirales order, including SARS-CoV-2, the agent of the COVID-19 pandemic. We conclude with improvements to the documentation of the resource through primers, tutorials and short videos. OMA is accessible at https://omabrowser.org.
Keywords
Algorithms, Animals, COVID-19/epidemiology, COVID-19/prevention & control, COVID-19/virology, Chromosome Mapping, Databases, Genetic, Evolution, Molecular, Gene Ontology, Gene Order/genetics, Genome/genetics, Humans, Internet, Pandemics, Phylogeny, SARS-CoV-2/genetics, SARS-CoV-2/physiology, Species Specificity, Synteny
Pubmed
Web of science
Open Access
Yes
Create date
16/11/2020 13:42
Last modification date
17/02/2021 6:27
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