Restoration of sinus rhythm with flecainide in patients with atrial fibrillation

Details

Serval ID
serval:BIB_A82415D2973F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Restoration of sinus rhythm with flecainide in patients with atrial fibrillation
Journal
American Journal of Cardiology
Author(s)
Goy  J. J., Kaufmann  U., Kappenberger  L., Sigwart  U.
ISSN
0002-9149 (Print)
Publication state
Published
Issued date
08/1988
Volume
62
Number
6
Pages
38D-40D
Notes
Journal Article --- Old month value: Aug 25
Abstract
The efficacy of flecainide acetate for conversion of atrial fibrillation into sinus rhythm was assessed in 69 patients (mean age of 63 +/- 14 years). Mean duration of the arrhythmia was 49 +/- 45 days. Mean cardiothoracic index was 0.49 +/- 0.03. Flecainide treatment was started intravenously with a bolus of 2 mg/kg over 10 minutes, followed by oral treatment (200 to 300 mg/day) according to body weight. Conversion to sinus rhythm was obtained in 49 patients (71%). The mean delay between initiation of treatment and restoration of sinus rhythm was 301 minutes (range 5 to 1,600). The left atrial diameter was smaller (40 +/- 1 mm) in patients who had successful cardioversion than in those who did not (46 +/- 1 mm) (p less than 0.05). Patients with atrial fibrillation lasting for less than 10 days had a higher conversion rate (79%) than patients with long-standing atrial fibrillation, in whom the conversion rate was only 38% (p less than 0.05). Conversion to sinus rhythm occurred in 33 patients during the first 5 minutes after injection. Adverse effects necessitated discontinuation of treatment in 4 patients (5.8%). Gastrointestinal disorders and dizziness occurred in 5 other patients but did not necessitate discontinuing treatment. In conclusion, flecainide is an effective drug for converting atrial fibrillation into sinus rhythm. Unlike quinidine, flecainide can be administered intravenously. The conversion rate with flecainide is higher in patients with a shorter duration of atrial fibrillation and smaller atria.
Keywords
Atrial Fibrillation/*drug therapy Electrocardiography Female Flecainide/administration & dosage/*therapeutic use Humans Male Middle Aged Time Factors
Pubmed
Web of science
Create date
15/02/2008 11:29
Last modification date
20/08/2019 15:12
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