A genomewide linkage study on suicidality in major depressive disorder confirms evidence for linkage to 2p12.

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Version: author
Serval ID
serval:BIB_A7EB97D5437F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A genomewide linkage study on suicidality in major depressive disorder confirms evidence for linkage to 2p12.
Journal
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Author(s)
Butler A.W., Breen G., Tozzi F., Craddock N., Gill M., Korszun A., Maier W., Middleton L.T., Mors O., Owen M.J., Perry J., Preisig M., Rice J.P., Rietschel M., Jones L., Farmer A.E., Lewis C.M., McGuffin P.
ISSN
1552-485X[electronic], 1552-4841[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
153B
Number
8
Pages
1465-1473
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Suicidal behavior is commonly associated with depression. Twin studies indicate that both suicidality and major depressive disorder (MDD) are heritable. However, epidemiological evidence suggests that the inheritance of suicidality is likely to be independent of the underlying psychiatric disorder, implying a distinct genetic contribution to suicidality. We conducted a genomewide linkage search aiming to detect genomic loci that may harbor susceptibility genes contributing to risk for suicidality in recurrent MDD. Affected sibling pair (ASP) variance components analysis was performed using the Depression Network cohort of 971 ASPs. The quantitative trait measuring suicidality as a broad phenotype, encompassing ideation and suicide attempts, was established from Schedules for Clinical Assessment in Neuropsychiatry interview items. We examined 1,060 genotyped microsatellite markers with an average spacing of 3.3 cM. Empirical thresholds for linkage evidence were set by whole-genome simulations (LOD = 2.71 for genomewide significance, 1.71 for suggestive linkage). No genomewide significant findings were found. Marker D3S1234 on 3p14 achieved suggestive linkage and yielded a maximum LOD of 1.853 (P = 0.0017), loci 9p24.3 and 18q22-q23 achieved LOD scores >1.5. We found some support for linkage to 2p12 (LOD = 1.2, P = 0.0087) which was previously implicated in linkage studies of suicidality. Our follow-up meta-analysis of five studies showed strong linkage to this region (P = 2 × 10(-6) ). In conclusion, this study analyzed suicidality as a continuous trait in MDD. We found modest evidence for linkage on 3p14. Our meta-analysis supports previous evidence of linkage to suicidality on 2p12. Some candidate genes in these regions may plausibly be implicated in suicidality.
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03/12/2010 11:07
Last modification date
20/08/2019 15:12
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