Cigarette tar yield and risk of upper digestive tract cancers: case-control studies from Italy and Switzerland

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Serval ID
serval:BIB_A7E274E177CA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cigarette tar yield and risk of upper digestive tract cancers: case-control studies from Italy and Switzerland
Journal
Annals of Oncology
Author(s)
Gallus  Silvano, Altieri  Andrea, Bosetti  Cristina, Franceschi  Silvia, Levi  Fabio, Negri  Eva, Dal Maso  Luigino, Conti  E., Zambon  Paola, La Vecchia  Carlo
ISSN
0923-7534
Publication state
Published
Issued date
2003
Volume
14
Number
2
Pages
209-213
Notes
Réf. IUMSP: R 03/05
SAPHIRID:44896
Abstract
BACKGROUND: Tobacco smoking is one of the main risk factors for oral, pharyngeal and oesophageal cancers in developed countries. Information on the role of the tar yield of cigarettes in upper digestive tract carcinogenesis is sparse and needs to be updated because the tar yield of cigarettes has steadily decreased over the last few decades. PATIENTS AND METHODS: We analysed two case-control studies, from Italy and Switzerland, conducted between 1992 and 1999, involving 749 cases of oral and pharyngeal cancer and 1770 controls, and 395 cases of squamous-cell oesophageal carcinoma and 1066 matched controls. Odds ratios (ORs) were estimated by unconditional multiple logistic regression models, including terms for age, sex, study centre, education and alcohol consumption. RESULTS: Based on the brand of cigarettes smoked for the longest time, the multivariate ORs for current smokers compared with never smokers were 6.1 for <20 mg and 9.8 for >or=20 mg tar for oral and pharyngeal neoplasms, and 4.8 and 5.4 for oesophageal cancer, respectively. For the cigarette brand smoked in the previous six months, the ORs for >or=10 mg compared with <10 mg were 1.9 for cancer of the oral cavity and pharynx and 1.8 for oesophageal cancer, after allowance for number of cigarettes and duration of smoking. CONCLUSIONS: The present study confirms the direct relationship between the tar yield of cigarettes and upper digestive tract neoplasms, and provides innovative information on lower tar cigarettes, which imply reduced risks compared with higher tar ones. However, significant excess risks were observed even in the lower tar category, thus giving unequivocal indications for stopping smoking as a priority for prevention of upper digestive tract neoplasms. [authors]
Pubmed
Web of science
Open Access
Yes
Create date
06/03/2008 15:31
Last modification date
25/09/2019 6:10
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