Protein level expression of Toll-like receptors 2, 4 and 9 in renal disease.

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Serval ID
serval:BIB_A7C82AEA7ED2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Protein level expression of Toll-like receptors 2, 4 and 9 in renal disease.
Journal
Nephrology, Dialysis, Transplantation
Author(s)
Batsford S., Duermueller U., Seemayer C., Mueller C., Hopfer H., Mihatsch M.
ISSN
1460-2385 (Electronic)
ISSN-L
0931-0509
Publication state
Published
Issued date
2011
Volume
26
Number
4
Pages
1413-1416
Language
english
Abstract
Background. Toll-like receptors (TLR) recognize a variety of ligands, including pathogen-associated molecular patterns and link innate and adaptive immunity. Individual receptors can be up-regulated during infection and inflammation. We examined the expression of selected TLRs at the protein level in various types of renal disease.Methods. Frozen sections of renal biopsies were stained with monoclonal antibodies to TLR-2, -4 and -9.Results. Up-regulation of the three TLRs studied was seen, although the extent was modest. TLR-2- and -4-positive cells belonged to the population of infiltrating inflammatory cells; only in the case of TLR-9 were intrinsic glomerular cells positive in polyoma virus infection and haemolytic uraemic syndrome (HUS).Conclusions. Evidence for the involvement of the three TLRs tested in a variety of human renal diseases was found. These findings add to our understanding of the role of the innate immune system in kidney disease.
Pubmed
Web of science
Open Access
Yes
Create date
06/05/2011 14:53
Last modification date
25/09/2019 6:10
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