Innervation of putative rapidly adapting mechanoreceptors by calbindin- and calretinin-immunoreactive primary sensory neurons in the rat.

Details

Serval ID
serval:BIB_A7BC86056D5A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Innervation of putative rapidly adapting mechanoreceptors by calbindin- and calretinin-immunoreactive primary sensory neurons in the rat.
Journal
European Journal of Neuroscience
Author(s)
Duc C., Barakat-Walter I., Droz B.
ISSN
0953-816X
Publication state
Published
Issued date
1994
Peer-reviewed
Oui
Volume
6
Number
2
Pages
264-271
Language
english
Abstract
Calbindin and calretinin are two homologous calcium-binding proteins that are expressed by subpopulations of primary sensory neurons. In the present work, we have studied the distribution of the neurons expressing calbindin and calretinin in dorsal root ganglia of the rat and their peripheral projections. Calbindin and calretinin immunoreactivities were expressed by subpopulations of large- and small-sized primary sensory neurons and colocalized in a majority of large-sized ones. The axons emerging from calbindin- or calretinin-immunoreactive neurons innervated muscle spindles, Pacini corpuscles and subepidermal lamellar corpuscles in the glabrous skin, formed palisades of lanceolate endings around hairs and vibrissae, and gave rise to intraepidermal nerve endings in the digital skin. Since most of these afferents are considered as rapidly adapting mechanoreceptors, it is concluded that calbindin- or calretinin-expressing neurons innervate particular mechanoreceptors that display physiological characteristics of rapid adaptation to stimuli.
Keywords
Aging, Animals, Calcium-Binding Protein, Vitamin D-Dependent, Ganglia, Spinal, Hair, Immunohistochemistry, Mechanoreceptors, Muscles, Nerve Tissue Proteins, Neurons, Afferent, Rats, Rats, Wistar, Skin, Tendons
Pubmed
Web of science
Create date
26/03/2009 11:26
Last modification date
20/08/2019 15:12
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