Association of clinical factors and recent anticancer therapy with COVID-19 severity among patients with cancer: a report from the COVID-19 and Cancer Consortium.

Grivas, P.; Khaki, A.R.; Wise-Draper, T.M.; French, B.; Hennessy, C.; Hsu, C.Y.; Shyr, Y.; Li, X.; Choueiri, T.K.; Painter, C.A.; Peters, S.; Rini, B.I.; Thompson, M.A.; Mishra, S.; Rivera, D.R.; Acoba, J.D.; Abidi, M.Z.; Bakouny, Z.; Bashir, B.; Bekaii-Saab, T.; Berg, S.; Bernicker, E.H.; Bilen, M.A.; Bindal, P.; Bishnoi, R.; Bouganim, N.; Bowles, D.W.; Cabal, A.; Caimi, P.F.; Chism, D.D.; Crowell, J.; Curran, C.; Desai, A.; Dixon, B.; Doroshow, D.B.; Durbin, E.B.; Elkrief, A.; Farmakiotis, D.; Fazio, A.; Fecher, L.A.; Flora, D.B.; Friese, C.R.; Fu, J.; Gadgeel, S.M.; Galsky, M.D.; Gill, D.M.; Glover, M.J.; Goyal, S.; Grover, P.; Gulati, S.; Gupta, S.; Halabi, S.; Halfdanarson, T.R.; Halmos, B.; Hausrath, D.J.; Hawley, J.E.; Hsu, E.; Huynh-Le, M.; Hwang, C.; Jani, C.; Jayaraj, A.; Johnson, D.B.; Kasi, A.; Khan, H.; Koshkin, V.S.; Kuderer, N.M.; Kwon, D.H.; Lammers, P.E.; Li, A.; Loaiza-Bonilla, A.; Low, C.A.; Lustberg, M.B.; Lyman, G.H.; McKay, R.R.; McNair, C.; Menon, H.; Mesa, R.A.; Mico, V.; Mundt, D.; Nagaraj, G.; Nakasone, E.S.; Nakayama, J.; Nizam, A.; Nock, N.L.; Park, C.; Patel, J.M.; Patel, K.G.; Peddi, P.; Pennell, N.A.; Piper-Vallillo, A.J.; Puc, M.; Ravindranathan, D.; Reeves, M.E.; Reuben, D.Y.; Rosenstein, L.; Rosovsky, R.P.; Rubinstein, S.M.; Salazar, M.; Schmidt, A.L.; Schwartz, G.K.; Shah, M.R.; Shah, S.A.; Shah, C.; Shaya, J.A.; Singh, SRK; Smits, M.; Stockerl-Goldstein, K.E.; Stover, D.G.; Streckfuss, M.; Subbiah, S.; Tachiki, L.; Tadesse, E.; Thakkar, A.; Tucker, M.D.; Verma, A.K.; Vinh, D.C.; Weiss, M.; Wu, J.T.; Wulff-Burchfield, E.; Xie, Z.; Yu, P.P.; Zhang, T.; Zhou, A.Y.; Zhu, H.; Zubiri, L.; Shah, D.P.; Warner, J.L.; Lopes, G.

doi:10.1016/j.annonc.2021.02.024

Association of clinical factors and recent anticancer therapy with COVID-19 severity among patients with cancer: a report from the COVID-19 and Cancer Consortium.

Details

Download: 33746047_BIB_A7A24C418B5A.pdf (597.71 [Ko])
State: Public
Version: Final published version
License: Not specified

Serval ID

serval:BIB_A7A24C418B5A

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Association of clinical factors and recent anticancer therapy with COVID-19 severity among patients with cancer: a report from the COVID-19 and Cancer Consortium.

Journal

Annals of oncology

Author(s)

Grivas P., Khaki A.R., Wise-Draper T.M., French B., Hennessy C., Hsu C.Y., Shyr Y., Li X., Choueiri T.K., Painter C.A., Peters S., Rini B.I., Thompson M.A., Mishra S., Rivera D.R., Acoba J.D., Abidi M.Z., Bakouny Z., Bashir B., Bekaii-Saab T., Berg S., Bernicker E.H., Bilen M.A., Bindal P., Bishnoi R., Bouganim N., Bowles D.W., Cabal A., Caimi P.F., Chism D.D., Crowell J., Curran C., Desai A., Dixon B., Doroshow D.B., Durbin E.B., Elkrief A., Farmakiotis D., Fazio A., Fecher L.A., Flora D.B., Friese C.R., Fu J., Gadgeel S.M., Galsky M.D., Gill D.M., Glover M.J., Goyal S., Grover P., Gulati S., Gupta S., Halabi S., Halfdanarson T.R., Halmos B., Hausrath D.J., Hawley J.E., Hsu E., Huynh-Le M., Hwang C., Jani C., Jayaraj A., Johnson D.B., Kasi A., Khan H., Koshkin V.S., Kuderer N.M., Kwon D.H., Lammers P.E., Li A., Loaiza-Bonilla A., Low C.A., Lustberg M.B., Lyman G.H., McKay R.R., McNair C., Menon H., Mesa R.A., Mico V., Mundt D., Nagaraj G., Nakasone E.S., Nakayama J., Nizam A., Nock N.L., Park C., Patel J.M., Patel K.G., Peddi P., Pennell N.A., Piper-Vallillo A.J., Puc M., Ravindranathan D., Reeves M.E., Reuben D.Y., Rosenstein L., Rosovsky R.P., Rubinstein S.M., Salazar M., Schmidt A.L., Schwartz G.K., Shah M.R., Shah S.A., Shah C., Shaya J.A., Singh SRK, Smits M., Stockerl-Goldstein K.E., Stover D.G., Streckfuss M., Subbiah S., Tachiki L., Tadesse E., Thakkar A., Tucker M.D., Verma A.K., Vinh D.C., Weiss M., Wu J.T., Wulff-Burchfield E., Xie Z., Yu P.P., Zhang T., Zhou A.Y., Zhu H., Zubiri L., Shah D.P., Warner J.L., Lopes G.

ISSN

1569-8041 (Electronic)

ISSN-L

0923-7534

Publication state

Published

Issued date

06/2021

Peer-reviewed

Oui

Volume

Number

Pages

787-800

Language

english

Notes

Publication types: Journal Article ; Research Support, N.I.H., Extramural
Publication Status: ppublish

Abstract

Patients with cancer may be at high risk of adverse outcomes from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We analyzed a cohort of patients with cancer and coronavirus 2019 (COVID-19) reported to the COVID-19 and Cancer Consortium (CCC19) to identify prognostic clinical factors, including laboratory measurements and anticancer therapies.
Patients with active or historical cancer and a laboratory-confirmed SARS-CoV-2 diagnosis recorded between 17 March and 18 November 2020 were included. The primary outcome was COVID-19 severity measured on an ordinal scale (uncomplicated, hospitalized, admitted to intensive care unit, mechanically ventilated, died within 30 days). Multivariable regression models included demographics, cancer status, anticancer therapy and timing, COVID-19-directed therapies, and laboratory measurements (among hospitalized patients).
A total of 4966 patients were included (median age 66 years, 51% female, 50% non-Hispanic white); 2872 (58%) were hospitalized and 695 (14%) died; 61% had cancer that was present, diagnosed, or treated within the year prior to COVID-19 diagnosis. Older age, male sex, obesity, cardiovascular and pulmonary comorbidities, renal disease, diabetes mellitus, non-Hispanic black race, Hispanic ethnicity, worse Eastern Cooperative Oncology Group performance status, recent cytotoxic chemotherapy, and hematologic malignancy were associated with higher COVID-19 severity. Among hospitalized patients, low or high absolute lymphocyte count; high absolute neutrophil count; low platelet count; abnormal creatinine; troponin; lactate dehydrogenase; and C-reactive protein were associated with higher COVID-19 severity. Patients diagnosed early in the COVID-19 pandemic (January-April 2020) had worse outcomes than those diagnosed later. Specific anticancer therapies (e.g. R-CHOP, platinum combined with etoposide, and DNA methyltransferase inhibitors) were associated with high 30-day all-cause mortality.
Clinical factors (e.g. older age, hematological malignancy, recent chemotherapy) and laboratory measurements were associated with poor outcomes among patients with cancer and COVID-19. Although further studies are needed, caution may be required in utilizing particular anticancer therapies.
NCT04354701.

Keywords

Aged, COVID-19, COVID-19 Testing, Female, Humans, Male, Neoplasms/drug therapy, Neoplasms/epidemiology, Pandemics, SARS-CoV-2, SARS-CoV2, anticancer therapy, cancer, laboratory measurements, neoplasm, outcomes

URN

urn:nbn:ch:serval-BIB_A7A24C418B5A8

OAI-PMH

oai:serval.unil.ch:BIB_A7A24C418B5A

DOI

10.1016/j.annonc.2021.02.024

Pubmed

33746047

Open Access

Yes

Create date

30/03/2021 11:03