Wnt signalling in cell division: from mechanisms to tissue engineering.

Details

Serval ID
serval:BIB_A7A1DD6825AE
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Wnt signalling in cell division: from mechanisms to tissue engineering.
Journal
Trends in cell biology
Author(s)
Habib S.J., Acebrón S.P.
ISSN
1879-3088 (Electronic)
ISSN-L
0962-8924
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Abstract
Wnt signalling is an essential player in tissue formation, notably in the regulation of stem cell function. Wnt signalling is best known for its roles in G1/S progression. However, a complex Wnt programme that also mediates mitotic progression and asymmetric cell division (ACD) is emerging. Recent developments in this area have provided mechanistic insights as well as tools to engineer or target Wnt signalling for translational and therapeutic purposes. Here, we discuss the bidirectional relationship between Wnt activity and mitosis. We emphasise how various Wnt-dependent mechanisms control spindle dynamics, chromosome segregation, and ACD. Finally, we illustrate how knowledge about these mechanisms has been successfully employed in tissue engineering for regenerative medicine applications.
Keywords
asymmetric cell division, bioengineering, chromosome segregation, localised Wnt signalling, spindle orientation, stem cells
Pubmed
Create date
05/07/2022 11:14
Last modification date
08/07/2022 6:35
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