Prospective study on procalcitonin and other systemic infection markers in patients with leukocytosis.

Details

Serval ID
serval:BIB_A79930B3CE1D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prospective study on procalcitonin and other systemic infection markers in patients with leukocytosis.
Journal
International Journal of Infectious Diseases
Author(s)
Indino Pamela, Lemarchand Pierre, Bady Pierre, De Torrenté Antoine, Genné Louis, Genné Daniel
ISSN
1201-9712
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
12
Number
3
Pages
319-324
Language
english
Abstract
OBJECTIVE: To better assess the diagnosis of an infection in patients presenting at an emergency department with peripheral blood leukocytosis (>10 x 10(9) cells/l) on laboratory testing. METHODS: We prospectively evaluated serum procalcitonin concentration (PCT), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). Patients were divided into two groups according to their final diagnosis: patients with infection and those without infection. PCT, CRP, and ESR were compared between these groups. Sensitivity, specificity, positive predictive values, negative predictive values, receiver operating characteristic curves, and areas under the curves were calculated for each biological measurement. RESULTS: Out of 173 patients, 99 (57%) had a final diagnosis of systemic infection. If a cutoff point of 0.5 ng/ml is considered, procalcitonin concentration had a sensitivity of 0.57, a specificity of 0.85, a negative predictive value of 0.59, and a positive predictive value of 0.84 for the diagnosis of a systemic infection. Adding CRP or ESR to PCT gave no more information (p=0.84). CONCLUSIONS: Only about half of the patients attending the emergency department with leukocytosis were suffering from an infection. Determination of the procalcitonin level may be useful for these patients, particularly in the case of a value higher than 0.5 ng/ml.
Keywords
Aged, Area Under Curve, Biological Markers/blood, Blood Sedimentation, C-Reactive Protein/analysis, Calcitonin/blood, Female, Humans, Infection/diagnosis, Leukocytosis/diagnosis, Leukocytosis/etiology, Male, Middle Aged, Predictive Value of Tests, Protein Precursors/blood, ROC Curve, Sensitivity and Specificity
Pubmed
Web of science
Open Access
Yes
Create date
03/02/2010 10:01
Last modification date
20/08/2019 15:12
Usage data