Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2

Details

Serval ID
serval:BIB_A795F9D316A5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2
Journal
Molecular and Cellular Neurosciences
Author(s)
Amaya  F., Decosterd  I., Samad  T. A., Plumpton  C., Tate  S., Mannion  R. J., Costigan  M., Woolf  C. J.
ISSN
1044-7431 (Print)
Publication state
Published
Issued date
04/2000
Volume
15
Number
4
Pages
331-42
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Apr
Abstract
The differential distribution of two tetrodotoxin resistant (TTXr) voltage-gated sodium channels SNS (PN3) and SNS2 (NaN) in rat primary sensory neurons has been investigated. Both channels are sensory neuron specific with SNS2 restricted entirely to those small dorsal root ganglion (DRG) cells with unmyelinated axons (C-fibers). SNS, in contrast, is expressed both in small C-fiber DRG cells and in 10% of cells with myelinated axons (A-fibers). All SNS expressing A-fiber cells are Trk-A positive and many express the vanilloid-like receptor VRL1. About half of C-fiber DRG neurons express either SNS or SNS2, and in most, the channels are colocalized. SNS and SNS2 are found both in NGF-responsive and GDNF-responsive C-fibers and many of these cells also express the capsaicin receptor VR1. A very small proportion of small DRG cells express either only SNS or only SNS2. At least four different classes of A- and C-fiber DRG neurons exist, therefore, with respect to expression of these sodium channels.
Keywords
Animals Antibody Specificity Biological Markers Blotting, Western Cell Line Ganglia, Spinal/cytology Humans In Situ Hybridization Intermediate Filament Proteins/analysis Kidney/cytology Male *Membrane Glycoproteins Molecular Sequence Data Nerve Fibers/chemistry/physiology Nerve Fibers, Myelinated/chemistry/physiology Nerve Tissue Proteins/analysis Neurofilament Proteins/analysis Neurons, Afferent/*chemistry/*physiology/ultrastructure Neuropeptides/analysis/genetics/immunology RNA, Messenger/analysis Rabbits Rats Rats, Sprague-Dawley Receptors, Drug/analysis Sequence Homology, Amino Acid Sodium Channels/*analysis/*genetics/immunology Tetrodotoxin
Pubmed
Web of science
Create date
28/01/2008 10:45
Last modification date
20/08/2019 15:12
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