Integrated multi-omics reveals cellular and molecular interactions governing the invasive niche of basal cell carcinoma.

Details

Serval ID
serval:BIB_A792039350C9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Integrated multi-omics reveals cellular and molecular interactions governing the invasive niche of basal cell carcinoma.
Journal
Nature communications
Author(s)
Yerly L., Pich-Bavastro C., Di Domizio J., Wyss T., Tissot-Renaud S., Cangkrama M., Gilliet M., Werner S., Kuonen F.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
20/08/2022
Peer-reviewed
Oui
Volume
13
Number
1
Pages
4897
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Tumors invade the surrounding tissues to progress, but the heterogeneity of cell types at the tumor-stroma interface and the complexity of their potential interactions hampered mechanistic insight required for efficient therapeutic targeting. Here, combining single-cell and spatial transcriptomics on human basal cell carcinomas, we define the cellular contributors of tumor progression. In the invasive niche, tumor cells exhibit a collective migration phenotype, characterized by the expression of cell-cell junction complexes. In physical proximity, we identify cancer-associated fibroblasts with extracellular matrix-remodeling features. Tumor cells strongly express the cytokine Activin A, and increased Activin A-induced gene signature is found in adjacent cancer-associated fibroblast subpopulations. Altogether, our data identify the cell populations and their transcriptional reprogramming contributing to the spatial organization of the basal cell carcinoma invasive niche. They also demonstrate the power of integrated spatial and single-cell multi-omics to decipher cancer-specific invasive properties and develop targeted therapies.
Keywords
Carcinoma, Basal Cell/pathology, Cell Communication, Extracellular Matrix/metabolism, Fibroblasts/metabolism, Humans, Skin Neoplasms/pathology
Pubmed
Open Access
Yes
Create date
25/08/2022 14:22
Last modification date
31/08/2022 6:40
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