Vitellogenesis and the vitellogenin gene family.

Details

Serval ID
serval:BIB_A763175E1B66
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Vitellogenesis and the vitellogenin gene family.
Journal
Science
Author(s)
Wahli W., Dawid I.B., Ryffel G.U., Weber R.
ISSN
0036-8075[print], 0036-8075[linking]
Publication state
Published
Issued date
04/1981
Volume
212
Number
4492
Pages
298-304
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
Vitellogenin is synthesized under estrogen control in the liver, extensively modified, transported to the ovary, and there processed to the yolk proteins lipovitellin and phosvitin. In the frog Xenopus laevis there are at least four distinct but related vitellogenin genes. The two genes A1 and A2 have a 95 percent sequence homology in their messenger RNA coding regions, and contain 33 introns that interrupt the coding region (exons) at homologous positions. Sequences and lengths of analogous introns differ, and many introns contain repetitive DNA elements. The introns in these two genes that have apparently arisen by duplication have diverged extensively by events that include deletions, insertions, and probably duplications. Rapid evolutionary change involving rearrangements and the presence of repeated DNA suggests that the bulk of the sequences within introns may not have any specific function.
Keywords
Animals, Base Sequence, Cloning, Molecular, DNA/genetics, Estrogens/physiology, Female, Genes, Lipoproteins/genetics, Liver/secretion, Male, Oocytes/metabolism, RNA, Messenger/metabolism, Receptors, Estrogen/metabolism, Repetitive Sequences, Nucleic Acid, Vitellogenins/biosynthesis, Vitellogenins/genetics, Xenopus laevis/genetics, Xenopus laevis/metabolism
Pubmed
Web of science
Create date
24/01/2008 16:04
Last modification date
20/08/2019 15:12
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