Premature ventricular contraction-induced cardiomyopathy: Related clinical and electrophysiologic parameters.

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State: Public
Version: Final published version
Serval ID
serval:BIB_A75241652F1D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Premature ventricular contraction-induced cardiomyopathy: Related clinical and electrophysiologic parameters.
Journal
Heart Rhythm : the Official Journal of the Heart Rhythm Society
Author(s)
Sadron Blaye-Felice M., Hamon D., Sacher F., Pascale P., Rollin A., Duparc A., Mondoly P., Derval N., Denis A., Cardin C., Hocini M., Jaïs P., Schlaepfer J., Bongard V., Carrié D., Galinier M., Pruvot E., Lellouche N., Haïssaguerre M., Maury P.
ISSN
1556-3871 (Electronic)
ISSN-L
1547-5271
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
13
Number
1
Pages
103-110
Language
english
Notes
Publication types: Journal Article ; Observational Study
Publication Status: ppublish
Abstract
BACKGROUND: Factors associated with premature ventricular contraction-induced cardiomyopathy (PVCi-CMP) remain debated.
OBJECTIVE: The purpose of this study was to test the correlation of various factors to the presence PVCi-CMP in a large multicenter population.
METHODS: One hundred sixty-eight consecutive patients referred for ablation of frequent premature ventricular contractions (PVCs) were included. Patients were divided into 2 groups: group 1 with suspected PVCi-CMP (96 patients, ejection fraction 38% ± 10%, left ventricular end-diastolic diameter 62 ± 8 mm, with or without additional structural heart disease); and group 2 (control group, 72 patients with normal ejection fraction and left ventricular dimensions). Various clinical and electrophysiologic parameters were compared between groups.
RESULTS: In univariate analysis, left ventricular origin of PVC, lack of palpitations, long PVC coupling interval, epicardial origin of the focus, long sinus beat QRS duration, male gender, high PVC burden, presence of polymorphic PVCs, high PVC QRS duration, and older age were significantly related to the presence of PVCi-CMP. In multivariate analysis, only lack of palpitations, PVC burden, and epicardial origin remained significantly and independently correlated with the presence of cardiomyopathy. Even if sinus QRS duration or PVC left ventricular origin were also found independently linked to PVCi-CMP in the whole population, they were no longer correlated when patients with additional heart disease were excluded.
CONCLUSION: Lack of palpitations, PVC burden, and epicardial origin are independent factors that identify patients prone to developing PVCi-CMP.
Keywords
Adult, Aged, Cardiomyopathies/diagnosis, Cardiomyopathies/etiology, Catheter Ablation/methods, Electrophysiologic Techniques, Cardiac/methods, Female, Humans, Male, Middle Aged, Retrospective Studies, Statistics as Topic, Stroke Volume, Ventricular Premature Complexes/complications, Ventricular Premature Complexes/diagnosis
Pubmed
Web of science
Create date
10/03/2016 15:32
Last modification date
20/08/2019 15:12
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