Urinary Sphincter Based on Electronics and Artificial Muscles

Details

Serval ID
serval:BIB_A7371A28E44B
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Urinary Sphincter Based on Electronics and Artificial Muscles
Title of the conference
38th Congress of the European Society for Artifi cial Organs (ESAO 2011) and 4th Biennial Congress of the International Federation on Artifi cial Organs (IFAO 2011)
Author(s)
Valerio M., Tozzi P., Wieland M., Hayoz D., Mundy A.R., Jichlinski P.
Address
Porto, Portugal, October 9-12, 2011
ISBN
0160-564X
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Series
Clinical Medicine. Life and Biomedical Sciences
Language
english
Abstract
Objectives: The AMS 800 is the current artifi cial urinary sphincter (AUS) forincontinence due to intrinsic sphincter defi ciency. Despite good clinical results,technical failures inherent to the hydraulic mechanism or urethral ischemicinjury contribute to revisions up to 60%. We are developing an electronic AUS,called ARTUS to overcome the rigors of AMS. The objective of this study wasto evaluate the technical effi cacy and tissue tolerance of the ARTUS systemin an animal model.Methods: The ARTUS is composed by three parts: thecontractile unit, a series of rings and an integrated microprocessor. The contractileunit is made of Nitinol fi bers. The rings are placed around the urethrato control the fl ow of urine by squeezing the urethra. They work in a sequentialalternative mode and are controlled by a microprocessor. In the fi rst phase athree-rings device was used while in the second phase a two-rings ARTUS wasused. The device was implanted in 14 sheep divided in two groups of six andeight animals for study purpose. The fi rst group aimed at bladder leak pointpressure (BLPP) measurement and validation of the animal model; the secondgroup aimed at verifying midterm tissue tolerance by explants at twelve weeks.General animal tolerance was also evaluated.Results: The ARTUS systemimplantation was uneventful. When the system was activated, the BLPP wasmeasured at 1.038 ± 0.044 bar (mean ± SD). Urethral tissue analysis did notshow signifi cant morphological changes. No infection and no sign of discomfortwere noted in animals at 12 weeks.Conclusions: The ARTUS proved to beeffective in continence achievement in this study. Histological results supportour idea that a sequential alternative mode can avoid urethral atrophy andischemia. Further technical developments are needed to verify long-termoutcome and permit human use.
Create date
28/12/2011 10:52
Last modification date
20/08/2019 15:12
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