Diabetes mellitus and vascular lesions.

Details

Serval ID
serval:BIB_A732983C30E7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Diabetes mellitus and vascular lesions.
Journal
Metabolism: clinical and experimental
Author(s)
Hayoz D., Ziegler T., Brunner H.R., Ruiz J.
ISSN
0026-0495
Publication state
Published
Issued date
1998
Peer-reviewed
Oui
Volume
47
Number
12 Suppl 1
Pages
16-9
Language
english
Notes
Publication types: Journal Article - Publication Status: ppublish
Abstract
Cardiovascular complications represent by far the most severe manifestations of diabetes mellitus. Treatment aimed at stopping progression of vascular lesions may fall short if initiated when the disease becomes clinically evident. Therefore, identification of the earliest vascular disfunctions may offer the best opportunity to interfere with pathogenic mechanisms and avoid progression of diabetic vasculopathy. In this report, we present a few mechanisms that alter hemodynamic and metabolic homeostasis in the course of diabetes mellitus. Endothelial function with special emphasis on nitric oxide and oxidative stress, advanced glycation end products, and the renin angiotensin system are briefly discussed. New pharmacological agents that may favorably influence these parameters are presently undergoing clinical trials. However, tight control of plasma glucose and cardiovascular risk factors represent the cornerstone of the treatment in diabetes to slow progression of vascular disease.
Keywords
Animals, Diabetic Angiopathies, Endothelium, Vascular, Humans, Models, Cardiovascular, Nitric Oxide, Renin-Angiotensin System, Stress, Mechanical
Pubmed
Web of science
Create date
17/01/2008 16:38
Last modification date
20/08/2019 15:12
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