Pressor responses of rats to vasopressin: effect of sodium, angiotensin, and catecholamines

Details

Serval ID
serval:BIB_A731341CD1D4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pressor responses of rats to vasopressin: effect of sodium, angiotensin, and catecholamines
Journal
American Journal of Physiology. Heart and Circulatory Physiology
Author(s)
Burnier  M., Brunner  H. R.
ISSN
0363-6135
Publication state
Published
Issued date
02/1983
Volume
244
Number
2
Pages
H253-8
Notes
Comparative Study Journal Article Research Support, Non-U.S. Gov't --- Old month value: Feb
Abstract
The pressor response to lysine vasopressin was tested in groups of male Wistar, Brattleboro, Wistar-Kyoto, and spontaneously hypertensive rats. Moreover, the influence of sodium intake, angiotensin II, saralasin, captopril, norepinephrine, and isoproterenol on vasopressin pressor responses was evaluated. The right iliac artery and one or both femoral veins of the animals were catheterized under light ether anesthesia. The experiments were carried out following a 2-h stabilization period with the rats awake and semirestrained. Pressor responsiveness was evaluated acutely on the basis of dose-response curves (0.5-4 mU). In the Wistar rats, angiotensin II (10 and 30 ng/min) and isoproterenol (10 ng/min) markedly decreased the response to vasopressin, whereas variations in sodium intake and blood pressure per se did not seem to exert any influence. Norepinephrine (250 ng/min) slightly enhanced the pressor responsiveness to the smaller doses of lysine-vasopressin. Brattleboro rats with congenital diabetes insipidus were less sensitive to vasopressin than the other animals, and neither angiotensin II nor isoproterenol induced any change. In conclusion, the pressor responsiveness to vasopressin can vary considerably depending on several factors. These must be taken into account when evaluating the possible pressor role of vasopressin in experimental and clinical settings.
Keywords
Angiotensin II/*analogs & derivatives/*pharmacology Animals Blood Pressure/*drug effects Captopril/*pharmacology Dose-Response Relationship, Drug Hypertension/physiopathology Isoproterenol/*pharmacology Lysine Vasopressin/*pharmacology Male Norepinephrine/*pharmacology Proline/*analogs & derivatives Rats Rats, Inbred Strains Saralasin/*pharmacology Sodium/*pharmacology Species Specificity
Pubmed
Web of science
Create date
25/01/2008 12:55
Last modification date
20/08/2019 15:12
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