Augmentation of bone defect healing using a new biocomposite scaffold: an in vivo study in sheep.

Details

Serval ID
serval:BIB_A72D60C6B749
Type
Article: article from journal or magazin.
Collection
Publications
Title
Augmentation of bone defect healing using a new biocomposite scaffold: an in vivo study in sheep.
Journal
Acta Biomaterialia
Author(s)
van der Pol U., Mathieu L., Zeiter S., Bourban P.E., Zambelli P.Y., Pearce S.G., Bouré L.P., Pioletti D.P.
ISSN
1878-7568[electronic], 1742-7061[linking]
Publication state
Published
Issued date
2010
Volume
6
Number
9
Pages
3755-3762
Language
english
Abstract
Previous studies support resorbable biocomposites made of poly(L-lactic acid) (PLA) and beta-tricalcium phosphate (TCP) produced by supercritical gas foaming as a suitable scaffold for tissue engineering. The present study was undertaken to demonstrate the biocompatibility and osteoconductive properties of such a scaffold in a large animal cancellous bone model. The biocomposite (PLA/TCP) was compared with a currently used beta-TCP bone substitute (ChronOS, Dr. Robert Mathys Foundation), representing a positive control, and empty defects, representing a negative control. Ten defects were created in sheep cancellous bone, three in the distal femur and two in the proximal tibia of each hind limb, with diameters of 5 mm and depths of 15 mm. New bone in-growth (osteoconductivity) and biocompatibility were evaluated using microcomputed tomography and histology at 2, 4 and 12 months after surgery. The in vivo study was validated by the positive control (good bone formation with ChronOS) and the negative control (no healing with the empty defect). A major finding of this study was incorporation of the biocomposite in bone after 12 months. Bone in-growth was observed in the biocomposite scaffold, including its central part. Despite initial fibrous tissue formation observed at 2 and 4 months, but not at 12 months, this initial fibrous tissue does not preclude long-term application of the biocomposite, as demonstrated by its osteointegration after 12 months, as well as the absence of chronic or long-term inflammation at this time point.
Keywords
Biocomposite, Bone substitute, In vivo, Poly(L-lactic acid), beta-Tricalcium phosphate, tissue engineering scaffolds, reinforced pla scaffolds, lactic-acid, biodegradable polymers, knee arthroplasty, degradation, composite, architecture, devices, repair
Pubmed
Web of science
Create date
15/09/2010 9:27
Last modification date
20/08/2019 16:12
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